- ￥880
- Bioss
- bs-15458P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-15458P |
| 英文名称 | HEPH Antibody Blocking Peptide |
| 中文名称 | 亚铁氧化酶封闭多肽 |
| 英文别名 | CPL; HEPH; HEPH_HUMAN; Hephaestin. |
| 纯化方法 | HPLC |
| 亚细胞定位 | Membrane; Single-pass type I membrane protein (Potential). |
| 组织特异性 | Detected in breast, colon, bone trabecular cells and fibroblasts. |
| 相似性 | Belongs to the multicopper oxidase family. Contains 6 plastocyanin-like domains. |
| 功能 | May function as a ferroxidase for ferrous (II) to ferric ion (III) conversion and may be involved in copper transport and homeostasis. Implicated in iron homeostasis and may mediate iron efflux associated to ferroportin 1. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Hephaestin is a single-pass type I membrane protein that belongs to the multicopper oxidase family of proteins. Hephaestin, a copper-dependant ferroxidase protein, is crucial for iron exiting intestinal enterocytes into the circulation. It mediates the movement of iron across the basolateral membrane in conjunction with ferroportin 1. This is an important link between iron and copper metabolism in mammalian systems, as copper deficiency leads to reduced hephaestin and reduced iron absorption resulting in anemia. Hephaestin can bind six copper ions per monomer and is regulated by the homeobox transcription factor CDX2. Increased levels of iron leads to an increase in CDX2 expression and thus Hephaestin. Hephaestin is primarily detected in the intestine, but is also expressed in colon, breast, bone trabecural cells and fibroblasts. |
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HEPH Antibody Blocking Peptide(bs-15458P)-500ug
￥880
