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- bs-15454P
- 2025年10月16日
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500ug
| 产品编号 | bs-15454P |
| 英文名称 | HENMT1 Antibody Blocking Peptide |
| 中文名称 | HEN1甲基转移酶同源蛋白1封闭多肽 |
| 英文别名 | C1orf59; HEN1; HEN1 methyltransferase homolog 1 (Arabidopsis); HEN1 methyltransferase homolog 1; HENMT_HUMAN; Henmt1; RP11-256E16.2; Small RNA 2''-O-methyltransferase; |
| 纯化方法 | HPLC |
| 研究领域 | Epigenetics and Nuclear Signaling > Chromatin Remodeling > Polycomb Silencing Epigenetics and Nuclear Signaling > DNA / RNA > RNA Processing |
| 亚细胞定位 | Cytoplasm (By similarity). Note=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon during meiosis (By similarity). |
| 相似性 | Belongs to the methyltransferase superfamily. HEN1 family. |
| 功能 | Methyltransferase that adds a 2'-O-methyl group at the 3'-end of piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. This probably protects the 3'-end of piRNAs from uridylation activity and subsequent degradation. Stabilization of piRNAs is essential for gametogenesis (By similarity). |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | C1orf59 is a 393 amino acid protein that belongs to the UPF0486 family. C1orf59 is considered a complete proteome and maps to chromosome 1p13.3. Chromosome 1 is the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration. The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis. Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome are also associated with chromosome 1. A breakpoint has been identified in 1q which disrupts the DISC1 gene and is linked to schizophrenia. Aberrations in chromosome 1 are found in a variety of cancers including head and neck cancer, malignant melanoma and multiple myeloma. |
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HENMT1 Antibody Blocking Peptide(bs-15454P)-500ug
￥880
