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- bs-14136P
- 2025年10月16日
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- 规格：
500ug
| 产品编号 | bs-14136P |
| 英文名称 | phospho-Cyclin C (Ser275) Antibody Blocking Peptide |
| 中文名称 | 磷酸化周期素C封闭多肽 |
| 英文别名 | Cyclin C (phospho S275); p-Cyclin C (phospho S275); CCNC; CCNC_HUMAN; CycC; Cyclin C; Cyclin-C; CyclinC; hSRB11; OTTHUMP00000016897; SRB11 homolog |
| 纯化方法 | HPLC |
| 研究领域 | Cell Biology > Cell Cycle > Cyclins Cell Biology > Cell Cycle > Cyclins > Other Cyclins Epigenetics and Nuclear Signaling > Cell cycle > Cyclins > Other Cyclins |
| 亚细胞定位 | Nucleus. |
| 组织特异性 | Highest levels in pancreas. High levels in heart, liver, skeletal muscle and kidney. Low levels in brain. |
| 翻译后修饰 | Phosphorylated upon DNA damage, probably by ATM or ATR. |
| 相似性 | Belongs to the cyclin family. Cyclin C subfamily. Contains 1 cyclin N-terminal domain. |
| 功能 | Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The protein encoded by this gene is a member of the cyclin family of proteins. The encoded protein interacts with cyclin-dependent kinase 8 and induces the phophorylation of the carboxy-terminal domain of the large subunit of RNA polymerase II. The level of mRNAs for this gene peaks in the G1 phase of the cell cycle. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
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phospho-Cyclin C (Ser275) Antibody Blocking Peptide(bs-14136P)-500ug
￥1080
