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- Bioss
- bs-11605P
- 2025年10月16日
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- 技术资料
- 规格：
500ug
| 产品编号 | bs-11605P |
| 英文名称 | TULP3 Antibody Blocking Peptide |
| 中文名称 | 感光细胞转录因子TULP3封闭多肽 |
| 英文别名 | Tubby like protein 3; Tubby related protein 3; Tubby-like protein 3; Tubby-related protein 3; TUBL 3; TUBL3; TULP 3; TULP3; TULP3_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Neuroscience > Neurology process > Neural Signal Transduction Neuroscience > Neurology process > Neurogenesis |
| 亚细胞定位 | Nucleus. Cell membrane. Cell projection, cilium (By similarity). Cytoplasm (By similarity). Secreted (By similarity). Note=Does not have a cleavable signal peptide and is secreted by a non-conventional pathway (By similarity). Translocates from the plasma membrane to the nucleus upon activation of guanine nucleotide-binding protein G(q) subunit alpha. |
| 组织特异性 | Expressed at high levels in testis, ovaries, thyroid, and spinal chord. |
| 相似性 | Belongs to the TUB family. |
| 功能 | Negatively regulates SHH signal transduction (By similarity). Probably functions in signal transduction from heterotrimeric G protein-coupled receptors. Binds to phosphorylated inositide lipids. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Mutations in the mouse Tub gene gradually lead to obesity, strongly resembling the late-onset obesity observed in the human population. In addition to excessive deposition of adipose tissue, mice with the Tub phenotype also suffer retinal degeneration and neurosensory hearing loss. A human homolog of the Tub gene has been identified, as have three related proteins, called Tubby-like protein 1 (TULP1), TULP2 and TULP3. When compared to TULP1 and TULP2, TULP3 has a wider tissue expression and is phylogenetically more similar to Tub than either TULP1 or TULP2. TULP1, expressed specifically in the retina, maps to the chromosomal region known to be involved in retinitis pigmentosa, while TULP2 maps within the minimal interval for the rod-cone dystrophy. TULP3 maps to human chromosome 12p13, and shares 69% homology to mouse TULP3. Human RNA from testis, ovary, thyroid and spinal cord contain highly detectable levels of TULP3 transcripts. In the retina, TULP3 is expressed specifically in the inner nuclear layer and ganglion cell layer. TULP1, TULP2 and TULP3 may comprise a unique family of bipartite transcription factors. |
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TULP3 Antibody Blocking Peptide(bs-11605P)-500ug
￥880
