- ￥880
- Bioss
- bs-12878P
- 2025年10月16日
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-12878P |
| 英文名称 | BORA Antibody Blocking Peptide |
| 中文名称 | 调节中心体分离早期相关激酶BORA封闭多肽 |
| 英文别名 | Aurora borealis; bora; BORA_HUMAN; C13orf34; Chromosome 13 open reading frame 34; FLJ22624; HsBora; Protein aurora borealis; RP11-342J4.2. |
| 纯化方法 | HPLC |
| 研究领域 | Cell Biology > Cell Cycle > Kinases/Phosphatases > Aurora Signal Transduction > Protein Phosphorylation > Ser / Thr Kinases > Aurora |
| 亚基 | Interacts with AURKA. |
| 翻译后修饰 | Phosphorylated by AURKA/STK6. |
| 相似性 | Belongs to the BORA family. |
| 功能 | Required for the activation of Aurora-A (AURKA/STK6) at the onset of mitosis. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Aurora related kinase-1 (ARK-1) is a centrosome-associated serine/threonine kinase that regulates centrosome separation, bipolar spindle assembly and chromosome segregation during mitosis. Bora (protein aurora borealis) is a 559 amino acid protein that activates ARK-1. Bora is localized to the nucleus until mitosis is initiated, when it then translocates to the cytoplasm. This translocation is dependent on activated Cdc2, which releases Bora to bind and activate ARK-1 in the cytoplasm. Plk (polo-like kinase) interacts with Bora to control the accessibility of its activation loop for phosphorylation and activation on its N-terminus by ARK-1. It is through this mechanism that Bora and ARK-1 control cellular mitotic entry. Downregulation of the gene encoding Bora results in multipolar spindles in mitosis, a phenomenon that is also observed when ARK-1 function is blocked. |
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
技术资料暂无技术资料 索取技术资料
BORA Antibody Blocking Peptide(bs-12878P)-500ug
￥880
