- ￥880
- Bioss
- bs-15425P
- 2025年10月16日
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500ug
| 产品编号 | bs-15425P |
| 英文名称 | RNGTT Antibody Blocking Peptide |
| 中文名称 | 5’-三磷酸聚核苷酸封闭多肽 |
| 英文别名 | RNGTT; CAP1A; GTase; GTP--RNA guanylyltransferase; hCAP; HCAP1; HcE; HCE1; MCE1; MCE1_HUMAN; mRNA 5''-triphosphatase; mRNA capping enzyme; mRNA guanyltransferase; mRNA guanylyltransferase; polynucleotide 5' trisphosphatase; RNA guanylyltransferase and 5' phosphatase; TPase; |
| 纯化方法 | HPLC |
| 研究领域 | Epigenetics and Nuclear Signaling > DNA / RNA > RNA Processing Epigenetics and Nuclear Signaling > Transcription > Elongation factors Epigenetics and Nuclear Signaling > Transcription > Other factors |
| 亚基 | Interacts with SUPT5H and RNMT. Interacts with HIV-1 Tat. |
| 亚细胞定位 | Nucleus. |
| 组织特异性 | Isoform 1 and isoform 4 (at a lesser extent) are expressed in cerebrum, cerebellum, thyroid, lung, heart, liver, kidney, spleen, large intestine, testis, skin and muscle. |
| 相似性 | In the N-terminal section; belongs to the non-receptor class of the protein-tyrosine phosphatase family. In the C-terminal section; belongs to the eukaryotic GTase family. |
| 功能 | Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the gmp moiety of GTP to the 5'-diphosphate terminus. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | RNGTT (RNA guanylyltransferase and 5'-phosphatase) is a 597 amino acid protein that localizes to the nucleus and exists as four alternatively spliced isoforms. Expressed in kidney, lung, heart, brain, liver, testis, skin and muscle, RNGTT acts as a bifunctional mRNA-capping enzyme that exhibits RNA 5'-triphosphatase activity at its N-terminus and mRNA guanylyltransferase activity at its C-terminus. Via its catalytic activity, RNGTT facilitates the first two steps of mRNA cap formation, naming the removal of a γ-phosphate from the end of nascent mRNA and the subsequent transfer of the phospho residue to the 5’-diphosphate terminus. The gene encoding RNGTT maps to human chromosome 6, which contains 170 million base pairs and comprises nearly 6% of the human genome. |
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RNGTT Antibody Blocking Peptide(bs-15425P)-500ug
￥880
