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- Bioss
- bs-21174P
- 2025年10月16日
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- 规格：
500ug
| 产品编号 | bs-21174P |
| 英文名称 | SH3PXD2B Antibody Blocking Peptide |
| 中文名称 | 脂肪细胞分化因子49封闭多肽 |
| 英文别名 | Adapter protein HOFI; Factor for adipocyte differentiation 49; FAD49; FLJ20831; FTHS; KIAA1295; SH3 and PX domain-containing protein 2B; SH3PXD2B; SPD2B_HUMAN; TKS4; Tyrosine kinase substrate with four SH3 domains. |
| 纯化方法 | HPLC |
| 研究领域 | Developmental Biology > Organogenesis > Skeletal development > Bone Signal Transduction > Adapters > Cytoplasmic Signal Transduction > Cytoskeleton / ECM > Extracellular Matrix > ECM Enzymes > ADAM Protein Family |
| 亚细胞定位 | Cytoplasm. Cell projection > podosome. Cytoplasmic in normal cells and localizes to podosomes in SRC-transformed cells. |
| 组织特异性 | Expressed in fibroblasts. |
| 翻译后修饰 | Phosphorylated in SRC-transformed cells. |
| 相似性 | Belongs to the SH3PXD2 family. Contains 1 PX (phox homology) domain. Contains 4 SH3 domains. |
| 功能 | Adapter protein involved in invadopodia and podosome formation and extracellular matrix degradation. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. Plays a role in mitotic clonal expansion during the immediate early stage of adipocyte differentiation (By similarity). |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | This gene encodes an adapter protein that is characterized by a PX domain and four Src homology 3 domains. The encoded protein is required for podosome formation and is involved in cell adhesion and migration of numerous cell types. Mutations in this gene are the cause of Frank-ter Haar syndrome (FTHS), and also Borrone Dermato-Cardio-Skeletal (BDCS) syndrome. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2015] |
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SH3PXD2B Antibody Blocking Peptide(bs-21174P)-500ug
￥880
