- ￥880
- Bioss
- bs-11744P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-11744P |
| 英文名称 | EN1 Antibody Blocking Peptide |
| 中文名称 | 同源盒蛋白转录因子EN1封闭多肽 |
| 英文别名 | EN1 / Engrailed 1; Engrailed1; En 1; EN1; EN-1; Engrailed; Engrailed homeobox 1; Engrailed homolog 1; HME1_HUMAN; Homeobox protein en-1; Homeobox protein engrailed 1; Homeobox protein engrailed-1; Homeobox protein engrailed-1; Hu-En-1; Mo-en.1. |
| 纯化方法 | HPLC |
| 研究领域 | Developmental Biology > Lineage specification > Ectoderm Epigenetics and Nuclear Signaling > Transcription > Domain Families > Developmental Families Epigenetics and Nuclear Signaling > Transcription > Other factors Neuroscience > Neurology process > Neurogenesis Stem Cells > Lineage Markers > Ectoderm Stem Cells > Signaling Pathways > Hedgehog > Nuclear |
| 亚细胞定位 | Nucleus. |
| 相似性 | Belongs to the engrailed homeobox family. Contains 1 homeobox DNA-binding domain. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The engrailed-1 gene, EN1, a murine homolog of the Drosophila homeobox gene engrailed (EN), is required for midbrain and cerebellum development and dorsal/ventral patterning of the limbs as well as apical ectodermal ridge formation. In Drosophila, the EN gene plays an important role during development in segmentation, where it is required for the formation of posterior compartments. Human EN-1 and EN-2 are homeodomain-containing proteins and have been implicated in the control of pattern formation during development of the central nervous system. Different mutations in the mouse homo-logs, EN-1 and EN-2, produce different developmental defects that frequently are lethal. EN-1 is highly expressed by essentially all dopaminergic neurons in the substantia nigra and ventral tegmentum. EN-1 and EN-2 regulate expres-sion of a-synuclein, a gene that is genetically linked to Parkinson’s disease. |
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EN1 Antibody Blocking Peptide(bs-11744P)-500ug
￥880
