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- Bioss
- bs-21170P
- 2025年10月16日
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- 规格：
500ug
| 产品编号 | bs-21170P |
| 英文名称 | SH3BGR Antibody Blocking Peptide |
| 中文名称 | SH3BGR蛋白封闭多肽 |
| 英文别名 | 21 GARP; 21 glutamic acid rich protein; 21-GARP; SH3 domain binding glutamic acid rich protein; SH3BGR; SH3BGR protein. |
| 纯化方法 | HPLC |
| 研究领域 | Epigenetics and Nuclear Signaling > DNA / RNA > RNA Processing > Splicing Neuroscience > Neurology process > Neurodegenerative disease Signal Transduction > Protein Trafficking > Nuclear Import / Export |
| 亚基 | Found in large molecular weight complexes containingCCNL1 and the p110 isoforms of either CDC2L1 or CDC2L2. Interactswith CCNL2 and CPSF6. |
| 亚细胞定位 | Nuclear |
| 组织特异性 | Brain, liver, kidney and lung. |
| 翻译后修饰 | Extensively phosphorylated on serine residues in the RSdomain. |
| 相似性 | Belongs to the splicing factor SR family.
Contains 1 CCHC-type zinc finger. Contains 1 RRM (RNA recognition motif) domain. |
| 功能 | Splicing factor, arginine/serine rich 7 is required for pre mRNA splicing. Can also modulate alternative splicing in vitro. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Pre-mRNA splicing enhancer elements are short RNA sequences capable of activating weak splice sites in nearby introns, and they are required for accurate splice site recognition and the control of alternative splicing (1). Splicing enhancer elements contain specific binding sites for serine/arginine (SR)-rich splicing factors, which include SC35, 9G8, SRp20, and SF2/ASF (2). The family of SR factors all contain one or more RNA recognition motifs (RRM) and an arginine/serine (RS)-rich domain, and they are essential for constitutive splicing and also regulate splicing in a concentration-dependent manner by influencing the selection of alternative splice sites (3,4). The majority of SR proteins, including SC35 and SRp40, are confined to the nucleus, while SF2/ASF, SRp20, and 9G8 are continuously shuttled between the nucleus and the cytoplasm and contribute to mRNA transport (5). The activity of SR proteins in regulated splicing is antagonized by members of the hnRNP A/B family of proteins, which induce drastic shifts in the selection of splicing-sites (6). |
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SH3BGR Antibody Blocking Peptide(bs-21170P)-500ug
￥880
