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- bs-14098P
- 2025年10月16日
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- 规格：
500ug
| 产品编号 | bs-14098P |
| 英文名称 | CTDSP1 Antibody Blocking Peptide |
| 中文名称 | 羧基端小结构域磷酸酶1封闭多肽 |
| 英文别名 | Carboxy terminal domain RNA polymerase II polypeptide A small phosphatase 1; Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1; CTD (carboxy terminal domain RNA polymerase II polypeptide A) small phosphatase 1; CTDS1_HUMAN; CTDSP1; NIF3; NLI IF; NLI interacting factor 3; NLI-IF; NLI-interacting factor 3; NLIIF; Nuclear LIM interactor interacting factor 3; Nuclear LIM interactor-interacting factor 3; SCP1; Small C-terminal domain phosphatase 1; Small CTD phosphatase 1. |
| 纯化方法 | HPLC |
| 研究领域 | Epigenetics and Nuclear Signaling > Nuclear Signaling Pathways > SMADs Epigenetics and Nuclear Signaling > Transcription > Polymerase associated factors > Pol II Transcription Signal Transduction > Signaling Pathway > Nuclear Signaling > SMADs |
| 亚细胞定位 | Nucleus. Colocalizes with RNA polymerase II. |
| 组织特异性 | Expression is restricted to non-neuronal tissues. Highest expression in skeletal muscle, spleen, lung and placenta. |
| 相似性 | Contains 1 FCP1 homology domain. |
| 功能 | Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residues repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | This gene encodes a member of the small C-terminal domain phosphatase (SCP) family of nuclear phosphatases. These proteins play a role in transcriptional regulation through specific dephosphorylation of phosphoserine 5 within tandem heptapeptide repeats of the C-terminal domain of RNA polymerase II. The encoded protein plays a role in neuronal gene silencing in non-neuronal cells, and may also inhibit osteoblast differentiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011] |
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CTDSP1 Antibody Blocking Peptide(bs-14098P)-500ug
￥880
