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- bs-1408P
- 2025年10月16日
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- 规格：
500ug
| 产品编号 | bs-1408P |
| 英文名称 | SMARCA4 Antibody Blocking Peptide |
| 中文名称 | 抑癌基因SNF2β封闭多肽 |
| 英文别名 | SMCA4_HUMAN; Transcription activator BRG1; EC:3.6.4.- ; ATP-dependent helicase SMARCA4; BRG1-associated factor 190A (BAF190A); Mitotic growth and transcription activator; Protein BRG-1; Protein brahma homolog 1; BAF190A; BRG1; SNF2B; SNF2L4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4; CSS4; SNF2; SWI2; MRD16; RTPS2; BAF190; OTSC12; SNF2LB; hSNF2b; SNF2-beta; |
| 纯化方法 | HPLC |
| 研究领域 | Cancer > Oncoproteins/suppressors > Tumor suppressors Epigenetics and Nuclear Signaling > Chromatin Remodeling > Swi / Snf Epigenetics and Nuclear Signaling > Chromatin Remodeling > Trithorax Neuroscience > Cell Type Marker > Neural Stem Cell marker Stem Cells > Signaling Pathways > Wnt > Nuclear |
| 亚基 | Belongs to the SNF2/RAD54 helicase family. Contains 1 bromo domain. Contains 1 helicase ATP-binding domain. Contains 1 helicase C-terminal domain. Contains 1 HSA domain. |
| 组织特异性 | Colocalizes with ZEB1 in E-cadherin-negative cells from established lines, and stroma of normal colon as well as in de-differentiated epithelial cells at the invasion front of colorectal carcinomas (at protein level). |
| 功能 | Transcriptional coactivator cooperating with nuclear hormone receptors to potentiate transcriptional activation. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. In addition, this protein can bind BRCA1, as well as regulate the expression of the tumorigenic protein CD44. Alternatively spliced transcripts have been found for this gene, but their full-length natures have not been determined. |
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SMARCA4 Antibody Blocking Peptide(bs-1408P)-500ug
￥880
