OBSCN Antibody Blocking Peptide(bs-21129P)-500ug

OBSCN Antibody Blocking Peptid

e(bs-21129P)-500ug
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  • bs-21129P
  • 2025年10月16日
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    北京博奥森生物技术有限公司
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      500ug

    产品编号bs-21129P
    英文名称OBSCN Antibody Blocking Peptide
    中文名称遮蔽蛋白肌球蛋白轻链激酶封闭多肽
    英文别名BC046431; Gm878; KIAA1556; KIAA1639; OBSCN; OBSCN_HUMAN; Obscurin; Obscurin-MLCK; Obscurin-myosin light chain kinase; Obscurin-RhoGEF; OTTMUSG00000005786; UNC89.
    纯化方法HPLC
    研究领域

    Developmental Biology > Organogenesis > Skeletal development > Muscle

    Signal Transduction > Cytoskeleton / ECM > Cytoskeleton > Motor Proteins > Myosin

    亚细胞定位Cytoplasm > myofibril > sarcomere > M line. Cytoplasm > myofibril > sarcomere > Z line. In differentiating skeletal muscle cells, isoform 3 primarily localizes to the sarcomeric M-line and less frequently to the Z-disk. Isoform 3 colocalizes with ANK1 isoform Mu17/ank1.5 at the M-line in differentiated skeletal muscle cells.
    相似性Belongs to the protein kinase superfamily.
    CAMK Ser/Thr protein kinase family.
    Contains 1 DH (DBL-homology) domain.
    Contains 3 fibronectin type-III domains.
    Contains 55 Ig-like (immunoglobulin-like) domains.
    Contains 1 IQ domain.
    Contains 2 PH domains.
    Contains 2 protein kinase domains.
    Contains 1 SH3 domain.
    功能Involved in myofibrillogenesis. Seems to be involved in assembly of myosin into sarcomeric A bands in striated muscle. Isoform 3 together with ANK1 isoform Mu17/Ank1.5 may provide a molecular link between the sarcoplasmic reticulum and myofibrils.
    保存条件Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料The obscurin gene spans more than 150 kb, contains over 80 exons and encodes a protein of approximately 720 kDa. The encoded protein contains 68 Ig domains, 2 fibronectin domains, 1 calcium/calmodulin-binding domain, 1 RhoGEF domain with an associated PH domain, and 2 serine-threonine kinase domains. This protein belongs to the family of giant sacromeric signaling proteins that includes titin and nebulin, and may have a role in the organization of myofibrils during assembly and may mediate interactions between the sarcoplasmic reticulum and myofibrils. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

     

     

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