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- Bioss
- bs-14066P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-14066P |
| 英文名称 | CROCC Antibody Blocking Peptide |
| 中文名称 | 睫状神经根卷曲螺旋蛋白封闭多肽 |
| 英文别名 | ciliary rootlet coiled coil; Ciliary rootlet coiled-coil protein; Crocc; CROCC_HUMAN; KIAA0445; Rootletin. |
| 纯化方法 | HPLC |
| 研究领域 | Tags & Cell Markers > Subcellular Markers > Organelles > Centrosome |
| 翻译后修饰 | Phosphorylated by NEK2 which may regulate its association with centrosomes. Phosphorylated upon DNA damage, probably by ATM or ATR. |
| 相似性 | Belongs to the rootletin family. |
| 功能 | Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus. Contributes to centrosome cohesion before mitosis. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | CROCC is a 2017 amino acid protein that forms centriole-associated fibrous structures and is an essential component of the ciliary rootlet. Localized to basal bodies and centrosomes in ciliated and nonciliated cells, respectively, Rootletin associates with the proximal ends of basal bodies and, in photoreceptors, functions to form elongated polymers between them. Rootletin is required for centrosome cohesion and, through interaction with C-Nap1 (a centrosomal protein present at the ends of the centrioles), can regulate the linkage of centrioles to basal bodies. Rootletin exists as a homopolymer whose association with centrosomes can be regulated via phosphorylation by Nek2 (NIMA-related kinase 2). Two isoforms exist due to alternative splicing events. |
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CROCC Antibody Blocking Peptide(bs-14066P)-500ug
￥880
