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- 2025年10月16日
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500ug
| 产品编号 | bs-11581P |
| 英文名称 | RAPGEF2 Antibody Blocking Peptide |
| 中文名称 | Rap鸟嘌呤核苷酸交换因子2封闭多肽 |
| 英文别名 | KIAA0313; Neural RAP guanine nucleotide exchange protein; nRap GEP; NRAPGEP; PDZ domain containing guanine nucleotide exchange factor 1; PDZ domain-containing guanine nucleotide exchange factor 1; PDZ GEF1; PDZ-GEF1; PDZGEF1; RA GEF; RA-GEF; Rap guanine nucleotide exchange factor 2; Rapgef2; RPGF2_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Neuroscience > Neurology process > Neural Signal Transduction Neuroscience > Neurotransmission > Receptors / Channels > GPCR > More GPCR Signal Transduction > Signaling Pathway > G Protein Signaling > Small G Proteins |
| 亚基 | Interacts with MAGI2. |
| 亚细胞定位 | Cell membrane (By similarity). Note=Associated with the synaptic plasma membrane |
| 组织特异性 | Highest expression levels in brain. Lower expression levels in heart, kidney, lung, and placenta. |
| 翻译后修饰 | Phosphorylation by PLK2 promotes its activity (By similarity). Phosphorylated upon DNA damage, probably by ATM or ATR. |
| 相似性 | Contains 1 cyclic nucleotide-binding domain. Contains 1 N-terminal Ras-GEF domain. Contains 1 PDZ (DHR) domain. Contains 1 Ras-associating domain. Contains 1 Ras-GEF domain. |
| 功能 | Guanine nucleotide exchange factor (GEF) for Rap1A, Rap1B and Rap2B GTPases. Does not interact with cAMP or cGMP. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | SummaryMembers of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF2, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM, Mar 2008] |
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文献和实验or from the literature are missing. In this article, processing parameters for DNA, peptide, antibody, and carbohydrate microarrays are outlined. The applicability of the model experiments is demonstrated and described in detail on the example of short oligonucleotides.
Synthesis and Probing of Membrane-bound Peptide Arrays
the stringency of the blocking conditions and make sure that the primary binding partner and detection reagent (e.g., antibody) are of high purity and are used in the highest possible dilution. Stage
Mapping Protein‐Protein Interactions with Phage‐Displayed Combinatorial Peptide Libraries
. Fack, F., Deroo, S., Kreis, S., and Muller, C.P. 2000. Heteroduplex mobility assay (HMA) pre‐screening: An improved strategy for the rapid identification of inserts selected from phage‐displayed peptide
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