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- bs-15398P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-15398P |
| 英文名称 | HSV1 Antibody Blocking Peptide |
| 中文名称 | 单纯疱疹病毒1型转录调节因子ICP22封闭多肽 |
| 英文别名 | Herpes simplex virus 1; Herpes Simplex Virus; Herpes Simplex Virus Type 1; HSV 1; Human herpesvirus 1; Human herpesvirus type 1; ICP22_HHV11; Transcriptional regulator ICP22; Immediate-early protein IE68; Infected cell protein 22; ICP22. |
| 纯化方法 | HPLC |
| 研究领域 | Microbiology > Organism > Virus > DNA Virus > double stranded DNA Virus > Herpes simplex |
| 亚细胞定位 | Host nucleus. Note=Localizes in small nuclear bodies early in infection then moves to a more diffuse distribution in viral compartments as infecion progresses. |
| 翻译后修饰 | Tyrosine phosphorylated. |
| 相似性 | Belongs to the herpesviridae IE68 family. |
| 功能 | Functions as a general transcriptional regulator of cellular and viral mRNAs mainly by mediating changes on the host RNA polymerase II. One change, which is UL13 independent, is the rapid loss of Pol II forms bearing Ser-2 phosphorylation. A second change, which is UL13 dependent, is the appearance of an intermediate form of Pol II that differs from the normal hypo- and hyperphosphorylated forms. These Pol II modifications immediately inhibit host genome transcription, leading to cell cycle deregulation and loss of efficient antiviral response. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Herpes simplex type 1 (HSV-1) belongs to a family that includes HSV-2, Epstein-Barr virus (EBV) and Varicella zoster (chicken pox) virus amongst others. HSV-1 and HSV-2 are extremely difficult to distinguish from each other. Members of this family have a characteristic virion structure. The double stranded DNA genome is contained within an icosahedral capsid embedded in a proteinaceous layer (tegument) and surrounded by a lipid envelope, derived from the nuclear membrane of the last host, which is decorated with virus-specific glycoproteins spikes. These viruses are capable of entering a latent phase where the host shows no visible sign of infection and levels of infectious agent become very low. During the latent phase the viral DNA is integrated into the genome of the host cell. |
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HSV1 Antibody Blocking Peptide(bs-15398P)-500ug
￥880
