- ￥880
- Bioss
- bs-2470P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-2470P |
| 英文名称 | CD244 Antibody Blocking Peptide |
| 中文名称 | CD244封闭多肽 |
| 英文别名 | NKR2B4; SLAMF4; natural killer cell receptor 2B4 isoform 2 precursor; 2B4 ; C9.1; CD244 antigen; CD244 molecule natural killer cell receptor 2B4; CD244 natural killer cell receptor 2B4; F730046O15Rik; h2B4; Ly90; NAIL; Natural killer cell activation-inducing ligand; Natural killer cell receptor 2B4; NK cell activation inducing ligand; NK cell activation inducing ligand NAIL; NK cell type I receptor protein 2B4; Nmrk; Non-MHC restricted killing associated; OTTHUMP00000027884; p38; SLAM family, member 4. |
| 纯化方法 | HPLC |
| 亚基 | Interacts with CD48. Following phosphorylation, it is able to recruit PTPN11/SHP-2 and SH2D1A/SAP. Binding of SH2D1A/SAP to CD244 prevents its association with PTPN11/SHP-2. |
| 亚细胞定位 | Membrane; Single-pass type I membrane protein (Potential). |
| 组织特异性 | Expressed in spleen, PBL, followed by lung, liver, testis and small intestine. Expressed not only in NK cells, but also on monocytes and basophils. |
| 相似性 | Contains 2 Ig-like (immunoglobulin-like) domains. |
| 功能 | Modulate other receptor-ligand interactions to enhance leukocyte activation. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | CD244 is expressed on all human NK cells, a subpopulation of T cells, basophils and monocytes. CD244 activates NK cell mediated cytotoxicity, induces secretion of IFN-gamma and matrix metalloproteinases, and NK cell invasiveness. Although there have been several molecules shown to interact with CD244, the signaling mechanism ofCD244-mediated activation of NK cells is still unknown. It is a high affinity receptor for CD48. |
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CD244 Antibody Blocking Peptide(bs-2470P)-500ug
￥880
