- ￥880
- Bioss
- bs-7756P
- 2025年10月16日
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-7756P |
| 英文名称 | PLEKHG6 Antibody Blocking Peptide |
| 中文名称 | 肌球蛋白相互作用G蛋白交换因子封闭多肽 |
| 英文别名 | Myosin interacting guanine nucleotide exchange factor; PH domain containing family G member 6; Pleckstrin homology domain containing family G (with RhoGef domain) member 6; Pleckstrin homology domain-containing family G member 6; PLEKHG6；PKHG6_HUMAN。 |
| 纯化方法 | HPLC |
| 研究领域 | Cancer > Signal transduction > G protein signaling > Small G proteins Cell Biology > Cell Cycle > Cell Division > Cytokinesis Signal Transduction > Cytoskeleton / ECM > Cytoskeleton > Motor Proteins > Myosin Signal Transduction > Signaling Pathway > G Protein Signaling > Small G Proteins > Regulators |
| 亚基 | Interacts with MYH10. Interacts with ELMO1 and EZR (in an open conformation). Interacts with CSPP1. |
| 亚细胞定位 | Cytoplasm. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Cleavage furrow. Note=During mitosis, localizes to the spindle pole, central spindle and cleavage furrow. In epithelial cells, recruited to the apical membrane by EZR. |
| 组织特异性 | Highest expression in the placenta. Low levels in small intestine, lung, liver, kidney, thymus and heart. |
| 相似性 | Contains 1 DH (DBL-homology) domain. Contains 1 PH domain. |
| 功能 | Guanine nucleotide exchange factor activating the small GTPase RHOA, which, in turn, induces myosin filament formation. Also activates RHOG. Does not activate RAC1, or to a much lower extent than RHOA and RHOG. Part of a functional unit, involving PLEKHG6, MYH10 and RHOA, at the cleavage furrow to advance furrow ingression during cytokinesis. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with EZR, required for normal macropinocytosis. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | MyoGEF functions as a guanine nucleotide exchange factor activating the small GTPase RHOA, which, in turn, induces myosin filament formation. It activates RHOG but not activate RAC1, or to a much lower extent than RHOA and RHOG. Part of a functional unit, involving MyoGEF, MYH10 and RHOA, at the cleavage furrow to advance furrow ingression during cytokinesis. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with EZR, required for normal macropinocytosis. |
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
技术资料暂无技术资料 索取技术资料
PLEKHG6 Antibody Blocking Peptide(bs-7756P)-500ug
￥880
