- ￥680 - 6880
- Bioss
- bs-43122P
- 2025年10月16日
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 技术资料
- 规格：
100ug/500ug/20ug
| 规格： | 100ug | 产品价格： | ￥2280.0 |
|---|---|---|---|
| 规格： | 500ug | 产品价格： | ￥6880.0 |
| 规格： | 20ug | 产品价格： | ￥680.0 |
| 产品编号 | bs-43122P |
| 英文名称 | Recombinant human Noggin protein (HEK293) |
| 中文名称 | 重组人指(趾)关节粘连NOG蛋白 |
| 英文别名 | NOG; SYM 1; SYM1; Symphalangism 1 (proximal); Synostoses (multiple) syndrome 1; SYNS 1; SYNS1; NOGG_HUMAN |
| 性状 | Lyophilized or Liqui |
| 纯化方法 | AC |
| 理论分子量 | 23 |
| 浓度 | ＞0.5 mg/ml |
| 储存液 | PBS (pH7.4). |
| 研究领域 | Developmental Biology > Embryogenesis > Morphogens Developmental Biology > Lineage specification > Ectoderm Stem Cells > Lineage Markers > Ectoderm Stem Cells > Signaling Pathways > TGF beta > Secreted |
| 亚基 | Homodimer. |
| 亚细胞定位 | Secreted. |
| 相似性 | Belongs to the noggin family. |
| 功能 | Essential for cartilage morphogenesis and joint formation. Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite |
| 保存条件 | Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Noggin is a secreted protein involved at multiple stages of vertebrate embryonic development including neural induction and is known to exert its effects by inhibiting the bone morphogenetic protein (BMP)-signaling pathway. It binds several BMPs with very high (picomolar) affinities, with a marked preference for BMP2 and BMP4 over BMP7. By binding tightly to BMPs, Noggin prevents BMPs from binding their receptors. Noggin binds the bone morphogenetic proteins (BMP) such as BMP-4 and BMP-7, and inhibits BMP signaling by blocking the molecular interfaces of the binding epitopes for both type I and type II receptors. Interaction of BMP and its antagonist Noggin governs various developmental and cellular processes, including embryonic dorsal-ventral axis, induction of neural tissue, formation of joints in the skeletal system and neurogenesis in the adult brain. Noggin plays a key role in neural induction by inhibiting BMP4, along with other TGF-β signaling inhibitors such as chordin and follistatin. Mouse knockout experiments have demonstrated that noggin also plays a crucial role in bone development, joint formation, and neural tube fusion. |
The purity of the protein is greater than 80% as determined by reducing SDS-PAGE.
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
技术资料暂无技术资料 索取技术资料
Recombinant human Noggin protein (HEK293)(bs-43122P)-100ug/500ug/20ug
￥680 - 6880
