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- bs-21033P
- 2025年10月16日
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- 规格：
500ug
| 产品编号 | bs-21033P |
| 英文名称 | SLIRP Antibody Blocking Peptide |
| 中文名称 | 14号染色体开放阅读框156封闭多肽 |
| 英文别名 | C14orf156; Chromosome 14 open reading frame 156; DC50; DC23; PD04872; SLIRP; SRA stem loop interacting RNA binding protein, mitochondrial. |
| 纯化方法 | HPLC |
| 研究领域 | Epigenetics and Nuclear Signaling > Chromatin Binding Proteins > DNA / RNA binding Epigenetics and Nuclear Signaling > Nuclear Signaling Pathways > Nuclear Receptors > Co-activators/co-repressors Signal Transduction > Signaling Pathway > Nuclear Signaling > Nuclear Hormone Receptors > Co-activators/co-repressors |
| 亚细胞定位 | Mitochondrial and Nuclear; Predominantly mitochondrial. |
| 组织特异性 | Ubiquitously expressed, with highest level in heart, liver, skeletal muscle and testis. |
| 相似性 | Contains 1 RRM (RNA recognition motif) domain. |
| 功能 | RNA-binding protein that acts as a nuclear receptor corepressor. Probably acts by binding the SRA RNA, and repressing the SRA-mediated nuclear receptor coactivation. Binds the STR7 loop of SRA RNA. Also able to repress glucocorticoid (GR), androgen (AR), thyroid (TR) and VDR-mediated transactivation. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Steroid receptor RNA activator (SRA, or SRA1; MIM 603819) is a complex RNA molecule containing multiple stable stem-loop structures that functions in coactivation of nuclear receptors. SLIRP interacts with stem-loop structure-7 of SRA (STR7) and modulates nuclear receptor transactivation (Hatchell et al., 2006 [PubMed 16762838]).[supplied by OMIM, Mar 2008] |
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SLIRP Antibody Blocking Peptide(bs-21033P)-500ug
￥880
