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- Bioss
- bs-12826P
- 2025年10月16日
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- 技术资料
- 规格：
500ug
| 产品编号 | bs-12826P |
| 英文名称 | STIM2 Antibody Blocking Peptide |
| 中文名称 | 基质交感分子2封闭多肽 |
| 英文别名 | FLJ39527; KIAA1482; STIM 2; STIM2; STIM2_HUMAN; stromal interaction molecule 2. |
| 纯化方法 | HPLC |
| 研究领域 | Signal Transduction > Signaling Pathway > Calcium Signaling |
| 亚细胞定位 | Endoplasmic reticulum membrane. Dynamically translocates from a uniform endoplasmic reticulum distribution to punctual endoplasmic reticulum-plasma membrane junctions in response to decrease in endoplasmic reticulum Ca(2+) concentration. |
| 组织特异性 | Expressed in all tissues and tumor cell lines examined. |
| 翻译后修饰 | Glycosylated. Phosphorylated predominantly on Ser residues. |
| 相似性 | Contains 1 EF-hand domain. Contains 1 SAM (sterile alpha motif) domain. |
| 功能 | Functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx. Regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRAC) channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca(2+) influx. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | This gene is a member of the stromal interaction molecule (STIM) family and likely arose, along with related family member STIM1, from a common ancestral gene. The encoded protein functions to regulate calcium concentrations in the cytosol and endoplasmic reticulum, and is involved in the activation of plasma membrane Orai Ca(2+) entry channels. This gene initiates translation from a non-AUG (UUG) start site. A signal peptide is cleaved from the resulting protein. Multiple transcript variants result from alternative splicing. [provided by RefSeq, Dec 2009] |
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STIM2 Antibody Blocking Peptide(bs-12826P)-500ug
￥880
