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- Bioss
- bs-12383P
- 2025年10月16日
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- 技术资料
- 规格：
500ug
| 产品编号 | bs-12383P |
| 英文名称 | HES2 Antibody Blocking Peptide |
| 中文名称 | 转录因子HES2封闭多肽 |
| 英文别名 | bHLHb40; Class B basic helix loop helix protein 40; Hairy and enhancer of split 2 (Drosophila); Transcription factor HES 2; HES2_HUMAN. |
| 纯化方法 | HPLC |
| 亚基 | Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE family (By similarity). |
| 亚细胞定位 | Nuclear. |
| 组织特异性 | Expressed in placenta, pancreatic cancer, colon cancer with RER, cervical cancer, and in head and neck tumors. |
| 相似性 | Contains 1 bHLH (basic helix-loop-helix) domain. Contains 1 Orange domain. |
| 功能 | Transcriptional repressor of genes that require a bHLH protein for their transcription. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The Drosophila hairy and Enhancer of split genes encode basic helix-loop-helix (bHLH) transcriptional repressors that function in the Notch signaling pathway and control segmentation and neural development during embryogenesis. The mammalian homologues of Drosophila hairy and Enhancer of split are the HES gene family members, HES1-6, which also encode bHLH transcriptional repressors that regulate myogenesis and neurogenesis. The HES family members form a complex with TLE, the mammalian homologue of Groucho, and this interaction is mediated by the carboxy terminal WRPW motif of the HES proteins. The HES/TLE complex functions by directly binding to DNA, instead of interfering with activator proteins. Most HES family members, including HES1 and HES5, preferentially bind to the N box (CACNAG) as opposed to the E box (CANNTG). HES2 binds to both N and E box sites, while HES6 does not bind DNA. Rather, HES6 inhibits HES1 activity, thereby promoting transcription. HES1 and HES2 are expressed in a variety of adult and embryonic tissues. HES3 is expressed exclusively in cerebellar Purkinje cells, and HES5 is found solely in the nervous system. HES6 is produced in brain as well as in the limb buds of developing embryos. |
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HES2 Antibody Blocking Peptide(bs-12383P)-500ug
￥880
