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- Bioss
- bs-21002P
- 2025年10月16日
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500ug
| 产品编号 | bs-21002P |
| 英文名称 | POLR1G Antibody Blocking Peptide |
| 中文名称 | RNA聚合酶II相关因子PAF49封闭多肽 |
| 英文别名 | A34.5; Anti sense to ERCC 1 protein; Antisense to ERCC-1 protein; ASE 1; ASE-1; ASE1; CAST; CD3 epsilon associated protein; CD3-epsilon-associated protein; CD3E antigen, epsilon polypeptide associated protein; CD3E associated protein; CD3e molecule, epsilon associated protein; CD3E-associated protein; CD3EAP; DNA directed RNA polymerase I subunit RPA34; DNA-directed RNA polymerase I subunit RPA34; MGC118851; PAF 49; RNA polymerase I associated factor PAF49; RNA polymerase I-associated factor PAF49; RPA34_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Epigenetics and Nuclear Signaling > Transcription > Polymerase associated factors > Pol I Transcription Epigenetics and Nuclear Signaling > Transcription > RNA polymerase |
| 亚细胞定位 | Nucleus > nucleolus. Chromosome. Found at the fibrillar centers of the nucleolus in interphase and during cell division it is localized to the nucleolus organizer regions of the chromosomes. |
| 翻译后修饰 | Isoform 2 undergoes tyrosine phosphorylation upon T-cell receptor (TCR) stimulation. This phosphorylation has not been confirmed by other group. Isoform 1 is phosphorylated on tyrosine residues in initiation-competent Pol I-beta complexes but not in Pol I-alpha complexes. Phosphorylated upon DNA damage, probably by ATM or ATR. |
| 相似性 | Belongs to the eukaryotic RPA34 RNA polymerase subunit family. |
| 功能 | DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Isoform 1 is involved in UBTF-activated transcription, presumably at a step following PIC formation. Isoform 2 has been described as a component of preformed T-cell receptor (TCR) complex. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | CD3EAP (CD3e Molecule Associated Protein) is a Protein Coding gene. Among its related pathways are RNA Polymerase I Promoter Escape and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. GO annotations related to this gene include poly(A) RNA binding and DNA-directed 5-3 RNA polymerase activity. |
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POLR1G Antibody Blocking Peptide(bs-21002P)-500ug
￥880
