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- bs-10949P
- 2025年10月16日
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- 规格：
500ug
| 产品编号 | bs-10949P |
| 英文名称 | ETV1 Antibody Blocking Peptide |
| 中文名称 | 转录因子ER81蛋白封闭多肽 |
| 英文别名 | DKFZp781L0674; ER81; ER81 protein; ETS translocation variant 1; ets variant gene 1; Ets-related protein 81; Etsrp81; ETV 1; ETV1; ETV1_HUMAN; MGC104699; MGC120533; MGC120534. |
| 纯化方法 | HPLC |
| 研究领域 | Epigenetics and Nuclear Signaling > Transcription > Domain Families > Ets Neuroscience > Neurology process > Neurogenesis Stem Cells > Hematopoietic Progenitors > Intracellular Molecules |
| 亚细胞定位 | Nucleus. |
| 组织特异性 | Very highly expressed in brain, highly expressed in testis, lung and heart, moderately in spleen, small intestine, pancreas and colon, weakly in liver, prostate and thymus, very weakly in skeletal muscle, kidney and ovary and not in placenta and peripheral blood leukocytes. |
| 翻译后修饰 | Sumoylated. |
| 相似性 | Belongs to the ETS family. Contains 1 ETS DNA-binding domain. |
| 功能 | Transcriptional activator that binds to DNA sequences containing the consensus pentanucleotide 5'-CGGA[AT]-3'. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Several members of the Ets gene family encode sequence-specific DNA binding proteins that recognize DNA sequences with a centrally located 5'-GGAA-3' element. All of the Ets proteins recognize the same central core sequence but each protein interacts with unique sequences that flank this core. PEA3 binds the motif 5'-AGGAAG-3', while ER81 (also designated ETV1) binds the motif 5'-CGGAA/T-3'. PEA3 is expressed at readily detectable levels in cells of epithelial and fibroblastic origin. Unlike other members of the Ets family, including Ets-1 and Ets-2, PEA3 is not expressed in hematopoietic cells. ER81 is highly expressed in brain, testis, lung and heart. ER81 is also moderately expressed in spleen, pancreas, colon and small intestine. During development, ER81, PEA3 and ERM display unique expression patterns which suggest these transcriptional factors play an important role in organogenesis. ERK-1 activates ER81 transcriptional activity, while MAPKAP kinase 2 inhibits ER81. |
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ETV1 Antibody Blocking Peptide(bs-10949P)-500ug
￥880
