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- Bioss
- bs-11484P
- 2025年10月16日
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- 技术资料
- 规格：
500ug
| 产品编号 | bs-11484P |
| 英文名称 | SLK Antibody Blocking Peptide |
| 中文名称 | 丝氨酸/苏氨酸蛋白激酶2封闭多肽 |
| 英文别名 | CTCL tumor antigen se20 9; LOSK; se20 9; Serine/threonine protein kinase 2; STK2; SLK; SNF1 sucrose nonfermenting like kinase; STE20 like serine/threonine-protein kinase; STE20 related kinase; STK2; SLK_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Cell Biology > Apoptosis > Intracellular > Kinases Neuroscience > Neurology process > Growth and Development > Axonal Guidance Proteins Neuroscience > Neurology process > Neurogenesis Signal Transduction > Signaling Pathway > Calcium Signaling |
| 亚细胞定位 | Cytoplasmic |
| 组织特异性 | Ubiquitously expressed. Highest expression is found in heart and in skeletal muscle. |
| 翻译后修饰 | Proteolytically cleaved by caspase-3. Autophosphorylated. Phosphorylated upon DNA damage, probably by ATM or ATR. |
| 相似性 | Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. Contains 1 protein kinase domain. Contains 1 UVR domain. |
| 功能 | SLK is a serine/threonine protein kinase that is involved in cytoskeletal reorganization and apoptosis. SLK is a microtubule-associated protein inducing actin stress fiber disassembly, it also mediates apoptosis and it is ubiquitously expressed; highest expression is found in heart and in skeletal muscle. There are two named isoforms. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | SLK is a member of the serine/threonine kinase subfamily, Ste20. This subfamily is comprised of several mammalian kinases which exhibit sequence similarity to the Saccharomyces cerevisiae serine/threonine kinase Ste20, a protein involved in relaying signals from G protein-coupled receptors to cytosolic MAP kinase cascades. Members of this subfamily include KHS, GLK, YSK1, HPK1, Krs-1, Krs-2, GC kinase, HGK and SLK. SLK is a ubiquitously expressed protein that localizes to the cytoplasm and contains an N-terminal protein kinase domain, a central coiled-coil domain and a C-terminal ATH domain. SLK is activated through cleavage by caspase-3. SLK indirectly associates with microtubules and plays an important role in cellular stress, cell motility, cell death and cytoskeletal dynamics. |
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SLK Antibody Blocking Peptide(bs-11484P)-500ug
￥880
