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- bs-11467P
- 2025年10月16日
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500ug
| 产品编号 | bs-11467P |
| 英文名称 | Neuron navigator 1 Antibody Blocking Peptide |
| 中文名称 | 神经细胞引领蛋白Nav1封闭多肽 |
| 英文别名 | Nav 1; Nav1; POMFIL 3; POMFIL3; Pore membrane and/or filament interacting like protein 3; Protein Steerin 1; Protein Steerin1; Steerin 1; Steerin1; unc-53 homolog 1; DKFZp781D0314; FLJ12560; FLJ14203; mNav1; NAV1_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Neuroscience > Neurology process > Growth and Development > Axonal Guidance Proteins Neuroscience > Neurology process > Neurogenesis |
| 亚基 | Interacts with tubulin |
| 亚细胞定位 | Cytoplasm, cytoskeleton. Note=Associates with a subset of microtubule plus ends. Enriched in neuronal growth cones. |
| 组织特异性 | Broadly expressed at low levels. Expressed at high levels in heart, skeletal muscle and placenta. |
| 相似性 | Belongs to the Nav/unc-53 family. |
| 功能 | The development of the nervous system (NS) requires the coordinated migration of multiple waves of neurons and subsequent processes of neurite maturation, both involving selective guidance mechanisms. In Caenorhabditis elegans, unc-53 codes for a new multidomain protein involved in the directional migration of a subset of cells. We describe here the first functional characterization of the mouse homologue, mouse Neuron navigator 1 (mNAV1) expression is primarily restricted to the CNS during development. mNAV1 is a microtubules associated protein. The abolition of mNAV1 causes loss of directionality in the leading processes of pontine-migrating cells, providing evidence for a role of mNAV1 in mediating (Netrin1-induced) directional migration. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Neuron navigator 1 is a 1877 amino acid cytoplasmic protein that is involved in neuronal migration. Neuron navigtor 1 is widely expressed at low levels, though highest expression is found in both adult and fetal nervous tissue. Through interaction with tubulin, Neuron navigator 1 associates with a subset of mirotubule plus ends present in the growth cone. Overexpression of Neuron navigator 1 leads to microtubule bundling, whereas a reduction of its levels causes loss of directionality in the migration of pontine cell leading processes. There are seven isoforms of Neuron navigator 1 that are produced as a result of alternative splicing events. |
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Neuron navigator 1 Antibody Blocking Peptide(bs-11467P)-500ug
￥880
