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- Bioss
- bs-0318P
- 2025年10月16日
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500ug
| 产品编号 | bs-0318P |
| 英文名称 | PADI4 Antibody Blocking Peptide |
| 中文名称 | 关节炎相关基因封闭多肽 |
| 英文别名 | EC 3.5.3.15; HL 60 PAD; HL-60 PAD; PAD 4; PAD; PADI 4; PADI 5; PADI H protein; PADI5; PDI 4; PDI 5; PDI4; PDI5; Padi4; PADI4_HUMAN; Peptidyl arginine deiminase type IV; Peptidyl arginine deiminase type V; Peptidylarginine deiminase IV; Protein arginine deiminase; Protein-arginine deiminase type IV; Protein-arginine deiminase type-4; Protein arginine deiminase type 4; Protein arginine deiminase type IV. |
| 性状 | Lyophilized |
| 纯化方法 | HPLC |
| 研究领域 | Epigenetics and Nuclear Signaling > Chromatin Modifying Enzymes > Arginine Deiminases Epigenetics and Nuclear Signaling > Chromatin Modifying Enzymes > Methylation > Arginine Deimination Metabolism > Pathways and Processes > Metabolic signaling pathways > Amino acid metabolism Signal Transduction > Metabolism > Amino Acids |
| 亚细胞定位 | Cytoplasm. Nucleus. Cytoplasmic granule. Note=Cytoplasmic granules of eosinophils and neutrophils. |
| 组织特异性 | Expressed in eosinophils and neutrophils, not expressed in peripheral monocytes or lymphocytes. |
| 翻译后修饰 | Autocitrullination at Arg-372 and Arg-374 inactivates the enzyme. |
| 相似性 | Belongs to the protein arginine deiminase family. |
| 功能 | Catalyzes the citrullination/deimination of arginine residues of proteins. Citrullinates histone H3 at 'Arg-8' and/or 'Arg-17' and histone H4 at 'Arg-3', which prevents their methylation by CARM1 and HRMT1L2/PRMT1 and represses transcription. Citrullinates EP300/P300 at 'Arg-2142', which favors its interaction with NCOA2/GRIP1. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | PADI4 (peptidyl arginine deiminase, type IV) catalyzes the deimination of arginine residues of proteins. Down-regulates histone H3 and H4 arginine methylation, both by preventing arginine methylation by CARM1 and HRMT1L2/PRMT1 and by converting methylarginine to citrulline. subcellular location at cytoplasmic granules. Belongs to the protein arginine deiminase family. This gene may play a role in granulocyte and macrophage development leading to inflammation and immune response. |
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PADI4 Antibody Blocking Peptide(bs-0318P)-500ug
￥880
