- ￥880
- Bioss
- bs-1682P
- 2025年10月16日
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- 详细信息
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- 规格：
500ug
| 产品编号 | bs-1682P |
| 英文名称 | CIB1 Antibody Blocking Peptide |
| 中文名称 | 钙整合素结合蛋白1封闭多肽 |
| 英文别名 | Sip2-28; Cibkip; Kip; Prkdcip; CIB1_HUMAN; Calcium and integrin-binding protein 1;CIB;Calcium- and integrin-binding protein;CIBP;Calmyrin;DNA-PKcs-interacting protein;Kinase-interacting protein;KIP;SNK-interacting protein 2-28;SIP2-28. |
| 纯化方法 | HPLC |
| 研究领域 | Signal Transduction > Cytoskeleton / ECM > Cell Adhesion > Integrins > Alpha Signal Transduction > Cytoskeleton / ECM > Cell Adhesion > Integrins > Beta Signal Transduction > Signaling Pathway > Calcium Signaling > Calcium Binding Proteins |
| 亚基 | Monomer. Interacts with the heterodimeric integrin alpha-IIb/beta3. Interacts with the protein kinases PLK2/SNK and with the region immediately upstream of the kinase domain of DNA-PK. Interacts with PLK3; leading to inhibit PLK3 kinase activity. Interacts with PSEN2. Interacts with MYO1C (By similarity). Interacts (via C-terminus) with F8. Interacts with NBR1 (via C-terminus). Interacts with FEZ1 (via C-terminus). Interacts with UBR5 (via C-terminus); the interaction is sensitive to DNA damage, and may target CIB1 for ubiquitin-mediated degradation. Interacts with IFI6. Interacts with BCL2. Interacts with TAS1R2 (via C-terminus); this interaction is independent of the myristoylation state of CIB1. Interacts with ITPR3; in a calcium dependent manner. Interacts with PTK2/FAK1. Interacts with MAP3K5; inhibiting MAP3K5 activation by phosphorylation, and its subsequent interaction with TRAF2. |
| 亚细胞定位 | Membrane. Cytoplasm. Nucleus. Cell projection, filopodium. Apical cell membrane. Localizes to the perinuclear region in the presence of NBR1. Colocalizes with TAS1R2 in apical regions of taste receptor cells. |
| 组织特异性 | Ubiquitous. |
| 相似性 | Contains 2 EF-hand domains. |
| 功能 | May convert the inactive conformation of integrin alpha-IIb/beta3 to an active form through binding to the integrin cytoplasmic domain. Induces cell migration and spreading mediated through integrin (possibly via focal adhesion complexes). Functions as a negative regulator of stress activated MAP kinase (MAPK) signaling pathways. May play a role in regulation of apoptosis. Interacts with and up-regulates PTK2 activity. Down regulates inositol 1,4,5-trisphosphate receptor-dependent calcium signaling. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | CIB1(Calcium and integrin binding 1) may convert the inactive conformation of integrin alpha-IIb/beta3 to an active form through the binding to the integrin cytoplasmic domain. |
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CIB1 Antibody Blocking Peptide(bs-1682P)-500ug
￥880
