- ￥880
- Bioss
- bs-11459P
- 2025年10月16日
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500ug
| 产品编号 | bs-11459P |
| 英文名称 | FARP2 Antibody Blocking Peptide |
| 中文名称 | 鸟嘌呤核苷酸交换因子FARP2封闭多肽 |
| 英文别名 | FARP 2; FERM; FGD1 related Cdc42 GEF; FIR; FRG; KIAA0793; PLEKHC3; RhoGEF and pleckstrin domain protein 2; FARP2_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Neuroscience > Neurology process > Growth and Development > Axonal Guidance Proteins Neuroscience > Neurology process > Neural Signal Transduction Neuroscience > Neurology process > Neuroregeneration > Neuroregeneration Signal Transduction > Signaling Pathway > G Protein Signaling > Small G Proteins > Ras Family Signal Transduction > Signaling Pathway > G Protein Signaling > Small G Proteins > Regulators |
| 亚基 | Interacts with PLXNA1. Interaction with PLXNA1 or PIP5K1C lowers its guanine nucleotide exchange activity. Dissociates from PLXNA1 when SEMA3A binds to the receptor. Interacts with PIP5K1C via its FERM domain. The interaction with PIP5K1C is enhanced by SEMA3A binding |
| 相似性 | Contains 1 DH (DBL-homology) domain.
Contains 1 FERM domain. Contains 2 PH domains. |
| 功能 | FARP2 is a Rho-guanine nucleotide exchange factor that activates RAC1. It plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | FARP2 is a 1,545 amino acid protein that contains one FERM domain, one DH domain and two PH domains. It exists as two alternatively spliced isoforms that are abundantly expressed in brain, lung, and testis as well as in embryonic hippocampal and cortical neurons. FARP2 functions as a Rho-guanine nucleotide exchange factor that activates RAC1 and is thought to regulate neurite remodeling of embryonic neurons. Sema3A binding to neuropilin-1 induces the dissociation of FARP2 from plexin-A1, thereby activating FARP2's Rac GEF activity which is critical for repulsion of outgrowing axons and suppression of neuronal adhesion. Downregulation of the FARP2 gene has been implicated in autism. |
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FARP2 Antibody Blocking Peptide(bs-11459P)-500ug
￥880
