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- bs-10920P
- 2025年10月16日
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500ug
| 产品编号 | bs-10920P |
| 英文名称 | LRP1/CD91 Antibody Blocking Peptide |
| 中文名称 | 低密度脂蛋白受体相关蛋白1封闭多肽 |
| 英文别名 | A2MR; Alpha 2 macroglobulin receptor; alpha 2MR; APOER; Apolipoprotein E receptor; APR; CD 91; CD91; CD91 antigen; Low density lipoprotein receptor related protein 1; Low density lipoprotein related protein 1; LRP 1; LRP 515; LRP 85; LRP; LRP ICD; LRP1; LRP1 protein; LRP515. |
| 纯化方法 | HPLC |
| 研究领域 | Cancer > Cell Death > Apoptosis > Metabolism Cancer > Cell Death > Apoptosis > Phagocytosis Cardiovascular > Atherosclerosis > Lipoprotein metabolism Cardiovascular > Blood > Serum Proteins Cardiovascular > Lipids / Lipoproteins > Lipid Metabolism > Cholesterol Metabolism Cell Biology > Apoptosis > Phagocytosis Metabolism > Pathways and Processes > Metabolic signaling pathways > Lipid and lipoprotein metabolism > Cholesterol Metabolism Metabolism > Pathways and Processes > Metabolic signaling pathways > Lipid and lipoprotein metabolism > Lipoprotein metabolism Metabolism > Pathways and Processes > Metabolism processes > Apoptosis Metabolism > Types of disease > Cancer Metabolism > Types of disease > Heart disease Metabolism > Types of disease > Neurodegenerative disease Metabolism > Types of disease > Obesity Neuroscience > Neurology process > Neurodegenerative disease > Alzheimer's disease Signal Transduction > Metabolism > Lipid metabolism |
| 亚基 | Heterodimer of an 85-kDa membrane-bound carboxyl subunit and a non-covalently attached 515-kDa N-terminal subunit. Intracellular domain interacts with MAFB (By similarity). Found in a complex with PID1/PCLI1, LRP1 and CUBNI. Interacts with SNX17, PID1/PCLI1, PDGF and CUBN. The intracellular domain interacts with SHC1, GULP1 and DAB1. Interacts with LRPAP1. Interacts with bacterial exotoxins. |
| 亚细胞定位 | Cell membrane. Membrane, coated pit and Cytoplasm. Nucleus. After cleavage, the intracellular domain (LRPICD) is detected both in the cytoplasm and in the nucleus. |
| 组织特异性 | Most abundant in liver, brain and lung. |
| 翻译后修饰 | Cleaved into a 85 kDa membrane-spanning subunit (LRP-85) and a 515 kDa large extracellular domain (LRP-515) that remains non-covalently associated. Gamma-secretase-dependent cleavage of LRP-85 releases the intracellular domain from the membrane. The N-terminus is blocked. Phosphorylated on serine and threonine residues. Phosphorylated on tyrosine residues upon stimulation with PDGF. Tyrosine phosphorylation promotes interaction with SHC1. |
| 相似性 | Belongs to the LDLR family. Contains 22 EGF-like domains. Contains 31 LDL-receptor class A domains. Contains 34 LDL-receptor class B repeats. |
| 功能 | Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission. Functions as a receptor for Pseudomonas aeruginosa exotoxin A. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | This gene encodes a member of the low-density lipoprotein receptor family of proteins. The encoded preproprotein is proteolytically processed by furin to generate 515 kDa and 85 kDa subunits that form the mature receptor (PMID: 8546712). This receptor is involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the alpha 2-macroglobulin-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer's disease patients. [provided by RefSeq, Oct 2015] |
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