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- Bioss
- bs-13992P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-13992P |
| 英文名称 | COREST Antibody Blocking Peptide |
| 中文名称 | COREST蛋白封闭多肽 |
| 英文别名 | COREST; KIAA0071; Protein CoREST; RCOR; RCOR1; RCOR1_HUMAN; REST corepressor 1. |
| 纯化方法 | HPLC |
| 研究领域 | Epigenetics and Nuclear Signaling > Chromatin Modifying Enzymes > Methylation |
| 亚细胞定位 | Nucleus. Upon infection by HSV-1, it is partially translocated into the cytoplasm in an HSV-1-dependent manner. |
| 组织特异性 | Ubiquitously expressed. |
| 翻译后修饰 | Phosphorylated by HSV-1 protein kinases in case of infection. |
| 相似性 | Belongs to the CoREST family. Contains 1 ELM2 domain. Contains 2 SANT domains. |
| 功能 | Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | This gene encodes a protein that is well-conserved, downregulated at birth, and with a specific role in determining neural cell differentiation. The encoded protein binds to the C-terminal domain of REST (repressor element-1 silencing transcription factor). [provided by RefSeq, Aug 2011] |
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COREST Antibody Blocking Peptide(bs-13992P)-500ug
￥880
