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- Bioss
- bs-2437P
- 2025年10月16日
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- 规格：
500ug
| 产品编号 | bs-2437P |
| 英文名称 | ENPP2 Antibody Blocking Peptide |
| 中文名称 | 自分泌运动因子封闭多肽 |
| 英文别名 | Autotaxin; Ectonucleotide pyrophosphatase/phosphodiesterase family member 2; ATX; ATX X; ATX-X; Autotaxin; E NPP 2; ENPP2; Ectonucleotide pyrophosphatase/phosphodiesterase 2; Extracellular lysophospholipase D; FLJ26803; LysoPLD; NPP2; PD IALPHA; PD-IALPHA; PDNP2; Phosphodiesterase I alpha; Phosphodiesterase I/nucleotide pyrophosphatase 2; Plasma lysophospholipase D; ENPP2_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Cancer > Tumor biomarkers > Enzymes Cardiovascular > Angiogenesis > Angiogenic Factors Cardiovascular > Atherosclerosis > Thrombosis Cardiovascular > Lipids / Lipoproteins > Lipid Metabolism > Lipases Metabolism > Pathways and Processes > Metabolic signaling pathways > Lipid and lipoprotein metabolism > Lipases Metabolism > Types of disease > Cancer Metabolism > Types of disease > Heart disease Neuroscience > Neurology process > Neurodegenerative disease Signal Transduction > Metabolism > Lipid metabolism |
| 亚细胞定位 | Secreted. Note=Secreted by most body fluids including serum and CSF. Also by adipocytes and numerous cancer cells. |
| 组织特异性 | Predominantly expressed in brain, placenta, ovary, and small intestine. Expressed in a number of carcinomas such as hepatocellular and prostate carcinoma, neuroblastoma and non-small-cell lung cancer. Expressed in body fluids such as plasma, cerebral spinal fluid (CSF), saliva, follicular and amniotic fluids. Not detected in leukocytes. Isoform 1 is more highly Eexpressed in peripheral tissues than in the central nervous system (CNS). Adipocytes only express isoform 1. Isoform 3 is more highly expressed in the brain than in peripheral tissues. |
| 翻译后修饰 | N-glycosylation, but not furin-cleavage, plays a critical role on secretion and on lysoPLD activity (By similarity). It has been suggested that the active SMB domain may be permitted considerable disulfide bond heterogeneity or variability, thus two alternate disulfide patterns based on 3D structures are described with 1 disulfide bond conserved in both. |
| 相似性 | Belongs to the nucleotide pyrophosphatase/phosphodiesterase family. Contains 2 SMB (somatomedin-B) domains. |
| 功能 | Hydrolyzes lysophospholipids to produce lysophosphatidic acid (LPA) in extracellular fluids. Major substrate is lysophosphatidylcholine. Also can act on sphingosylphosphphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility. Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP. Involved in several motility-related processes such as angiogenesis and neurite outgrowth. Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation. Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein. May have a role in induction of parturition. Possible involvement in cell proliferation and adipose tissue development. Tumor cell motility-stimulating factor. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Hydrolyzes lysophospholipids to produce lysophosphatidic acid (LPA) in extracellular fluids. Major substrate is lysophosphatidylcholine. Also can act on sphingosylphosphphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility. Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP. Involved in several motility-related processes such as angiogenesis and neurite outgrowth. Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation. Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein. May have a role in induction of parturition. Possible involvement in cell proliferation and adipose tissue development. Tumor cell motility-stimulating factor. |
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ENPP2 Antibody Blocking Peptide(bs-2437P)-500ug
￥880
