Recombinant protein A, AP conjugated(bs-0362P-AP)-100ul

Recombinant protein A, AP conj

ugated(bs-0362P-AP)-100ul
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  • bs-0362P-AP
  • 2025年10月16日
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      100ul

    产品编号bs-0362P-AP
    英文名称Recombinant protein A, AP conjugated
    中文名称碱性磷酸酶标记的蛋白A
    英文别名Protein A / AP
    性状Liquid
    储存液10mM TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Tags & Cell Markers > Fusion / Marker Proteins > Protein A

    亚细胞定位Secreted; cell wall.
    保存条件Stored at 2-8℃ for one year.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料Protein A is a 40-60 kDa surface protein originally found in the cell wall of the bacteria Staphylococcus aureus (SPA). SPA binds proteins from many of mammalian species, most notably IgGs, and helps inhibit phagocytic engulfment and acts as an immunological disguise via this type of interaction, thus the bacteria will disrupts opsonization and phagocytosis. SPA is known to bind with Fc region of immunoglobulins preferentially through interaction with the VH3 variable region of the heavy chain. SPA has been shown to bind with high affinity to human IgG1 and IgG2 as well as mouse IgG2a and IgG2b, whereas bind with moderate affinity to human IgM, IgA and IgE as well as mouse IgG3 and IgG1. SPA is often produced in E. coli and is practically coupled to other molecules such as enzymes, biotin, radioactive iodine for use in immunology and other biological research. SPA is also immobilized onto solid supports such as agarose beads for total IgG purifying or interest protein or protein complex identifying in immunoprecipitation studies.

     

     

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