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- Bioss
- bs-16765P
- 2025年10月16日
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- 规格：
500ug
| 产品编号 | bs-16765P |
| 英文名称 | KLHL17 Antibody Blocking Peptide |
| 中文名称 | Kelch样蛋白17封闭多肽 |
| 英文别名 | Actinfilin; AL022703; BC058738; kelch like 17; kelch like family member 17; kelch like protein 17; Kelch-like protein 17; KLH17_HUMAN; Klhl17; RP11-54O7.6. |
| 纯化方法 | HPLC |
| 研究领域 | Cell Biology > Proteolysis / Ubiquitin > Proteasome / Ubiquitin > Ubiquitin E3 Enzymes > Other E3 Ligases Epigenetics and Nuclear Signaling > Chromatin Modifying Enzymes > Ubiquitylation Signal Transduction > Cytoskeleton / ECM > Cytoskeleton > Microfilaments > Actin etc > Actin |
| 亚基 | Interacts with F-actin; the interaction disruptes the F-actin structures and leads to marked changes of neuronal morphology. |
| 亚细胞定位 | Cell junction > synapse > postsynaptic cell membrane > postsynaptic density. Cell junction > synapse. Postsynaptic density. |
| 相似性 | Contains 1 BACK (BTB/Kelch associated) domain. Contains 1 BTB (POZ) domain. Contains 6 Kelch repeats. |
| 功能 | Substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(KLHL17) mediates the ubiquitination and subsequenct degradation of GLUR6. May play a role in the actin-based neuronal function. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The protein encoded by this gene is expressed in neurons of most regions of the brain. It contains an N-terminal BTB domain, which mediates dimerization of the protein, and a C-terminal Kelch domain, which mediates binding to F-actin. This protein may play a key role in the regulation of actin-based neuronal function. [provided by RefSeq, Aug 2010] |
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KLHL17 Antibody Blocking Peptide(bs-16765P)-500ug
￥880
