- ￥880
- Bioss
- bs-10784P
- 2025年10月16日
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500ug
| 产品编号 | bs-10784P |
| 英文名称 | SPTBN2 + SPTBN1 Antibody Blocking Peptide |
| 中文名称 | 非红细胞血影脑蛋白β2/spectrin β III封闭多肽 |
| 英文别名 | Beta III spectrin; Beta-III spectrin; SCA 5; SCA5; Spectrin beta chain brain 2; Spectrin beta non erythrocytic 2; Spectrin non erythroid beta chain 2; Spinocerebellar ataxia 5; SPTBN 2; Spectrin beta chain, non-erythrocytic 2; Beta-III spectrin; Spinocerebellar ataxia 5 protein; SPTN2_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Epigenetics and Nuclear Signaling > ChIP assays > ChIP kits Neuroscience > Neurology process > Neurodegenerative disease Signal Transduction > Cytoskeleton / ECM > Cytoskeleton > Microfilaments > Actin etc > Actin Binding Proteins |
| 亚细胞定位 | Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. |
| 组织特异性 | Highly expressed in brain, kidney, pancreas, and liver, and at lower levels in lung and placenta. |
| 相似性 | Belongs to the spectrin family.
Contains 2 CH (calponin-homology) domains. Contains 1 PH domain. Contains 17 spectrin repeats. |
| 功能 | Probably plays an important role in neuronal membrane skeleton. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Spectrin is an actin binding protein that is a major component of the plasma membrane skeleton. Spectrins function as membrane organizers and stabilizers by forming dimers, tetramers and higher polymers. Spectrin Alpha and spectrin Beta are present in erythrocytes, whereas spectrin Alpha II (also designated fodrin Alpha) and spectrin Beta I (also designated fodrin Beta) are present in other somatic cells. The spectrin tetramers in erythrocytes act as barriers to lateral diffusion, but spectrin dimers seem to lack this function. Spectrin Beta III is highly homologous to both spectrin Beta I and spectrin Beta II. Western blot analysis shows that spectrin Beta III migrates at a higher molecular mass than predicted in the kidney. Spectrin Beta III is highly expressed in brain, kidney, pancreas, and liver, and at lower levels in lung and placenta. Specifically, spectrin Beta III constitutes a major component of the Golgi and vesicular membrane skeletons. |
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SPTBN2 + SPTBN1 Antibody Blocking Peptide(bs-10784P)-500ug
￥880
