- ￥880
- Bioss
- bs-11382P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-11382P |
| 英文名称 | A4GNT Antibody Blocking Peptide |
| 中文名称 | α1,4-N-乙酰葡糖胺转移酶α4Gn-T封闭多肽 |
| 英文别名 | 4-N-acetylglucosaminyltransferase; A4GCT_HUMAN; A4GNT; Alpha 1 4 N acetylglucosaminyltransferase; Alpha-1; Alpha4GnT; EC 2.4.1.; MGC149493. |
| 纯化方法 | HPLC |
| 亚细胞定位 | Golgi apparatus membrane. |
| 组织特异性 | Detected in stomach and pancreas. |
| 相似性 | Belongs to the glycosyltransferase 32 family. |
| 功能 | Necessary for the synthesis of type III mucin. Catalyzes the transfer of N-acetylglucosamine (GlcNAc) to core 2 branched O-glycans. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Alpha 1,4-N-acetylflucosaminyltransferase (Alpha4Gn-T) mediates the biosynthesis of mucin type glycoprotein (O-glycan). Alpha4Gn-T acts as the key enzyme for the formation of the unique glycan GlcNAcalpha1-4Galbeta1-R, and most efficiently transfers N-acetylglucosamine (GlcNAc) to core 2 branched O-glycans. Alpha4Gn-T is a single-pass type II membrane protein associated with the Golgi apparatus and contains the conserved DXD motif involved in catalytic activity. It is expressed in stomach and pancreas, as well as in gastric cancer cells. Alpha4Gn-T is not expressed in peripheral blood cells, making it a useful biomarker for pancreatic cancer. Alpha4Gn-T and Mucin 6 expression is upregulated in the gastric mucosa of H.pylori infected patients, which suggest the involvement of ?Gn-T in defense against H. pylori infection. |
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A4GNT Antibody Blocking Peptide(bs-11382P)-500ug
￥880
