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- bs-10730P
- 2025年10月16日
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- 规格：
500ug
| 产品编号 | bs-10730P |
| 英文名称 | phospho-PIK3R3 (Tyr199) Antibody Blocking Peptide |
| 中文名称 | 磷酸化磷脂酰肌醇激酶调节亚单位gamma封闭多肽 |
| 英文别名 | phospho-PI 3 Kinase p55 gamma (Tyr199); PI 3 Kinase p55 gamma (phospho Y199); PIK3R3; PI3-kinase regulatory subunit gamma (phospho Tyr199); P55G_HUMAN; Phosphatidylinositol 3-kinase regulatory subunit gamma; PI3-kinase regulatory subunit gamma; PI3K regulatory subunit gamma; PtdIns-3-kinase regulatory subunit gamma; Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma; PI3-kinase subunit p55-gamma; PtdIns-3-kinase regulatory subunit p55-gamma; p55PIK; p55; p55-GAMMA; phosphoinositide-3-kinase, regulatory subunit 3 (gamma). |
| 纯化方法 | HPLC |
| 亚基 | Heterodimer of a regulatory subunit PIK3R3 and a p110 catalytic subunit (PIK3CA, PIK3CB or PIK3CD). Interacts with AXL. |
| 组织特异性 | Highest levels in brain and testis. Lower levels in adipose tissue, kidney, heart, lung and skeletal muscle. |
| 相似性 | Belongs to the PI3K p85 subunit family.
Contains 2 SH2 domains. |
| 功能 | Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The enzyme phosphatidylinositol 3 kinase (PI3 kinase) is a lipid kinase that generates phosphatidylinositol 3, 4, 5-triphosphate in response to receptor activation in many signal transduction pathways. Class IA PI3Ks exist as a heterodimer of a catalytic 110 kDa (p110) and a regulatory p85 subunit (e.g. p85 alpha). p85 alpha is an adaptor molecule that regulates the activity of the catalytic p110 subunit by binding to phosphorylated receptor tyrosine kinases (RTKs) through its SH2 domain and mediating the interaction between p110 and the plasma membrane. p85 alpha is necessary for insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. |
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phospho-PIK3R3 (Tyr199) Antibody Blocking Peptide(bs-10730P)-500ug
￥1080
