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- Bioss
- bs-14416P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-14416P |
| 英文名称 | DPH3 Antibody Blocking Peptide |
| 中文名称 | DPH3蛋白封闭多肽 |
| 英文别名 | CSL-type zinc finger-containing protein 2; Deafness locus putative guanine nucleotide exchange factor interacting protein 1; DelGEF-interacting protein 1; DELGIP; DelGIP1; DESR1; Diphtheria toxin and Pseudomonas exotoxin A sensitivity required gene 1; DPH3; DPH3 homolog; DPH3 KTI11 homolog; DPH3_HUMAN; DPH3A; KTI11; MGC20197; ZCSL2; Zinc finger CSL domain containing 2; Zinc finger CSL type containing 2. |
| 纯化方法 | HPLC |
| 亚细胞定位 | Cytoplasm. Nucleus. |
| 组织特异性 | Widely expressed with highest levels in small intestine, spleen, thymus, heart, liver and lung. |
| 相似性 | Belongs to the DPH3 family. Contains 1 DPH-type zinc finger. |
| 功能 | Essential for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in elongation factor 2 and which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A. Down-regulation increases extracellular release of proteoglycans, indicating a possible role in the secretion process. Stimulates binding of GNEFR to SEC5. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | This gene encodes a CSL zinc finger-containing protein that is required for dipthamide biosynthesis. The encoded protein is necessary for the initial step in the modification of a histidine residue in elongation factor-2 to diphthamide. This modified residue is a target for ADP ribosylation by the bacterial toxins diphtheria toxin and Pseudomonas exotoxin A. Alternative splicing results in multiple transcript variants that encode the same isoform. [provided by RefSeq, Feb 2009] |
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DPH3 Antibody Blocking Peptide(bs-14416P)-500ug
￥880
