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- Bioss
- bs-10720P
- 2025年10月16日
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- 技术资料
- 规格：
500ug
| 产品编号 | bs-10720P |
| 英文名称 | SPFH2 Antibody Blocking Peptide |
| 中文名称 | 内质网脂质转运相关蛋白2封闭多肽 |
| 英文别名 | C8orf2; Chromosome 8 open reading frame 2; Endoplasmic reticulum lipid raft associated protein 2; Endoplasmic reticulum lipid raft-associated protein 2; ER lipid raft associated 2; ERLIN 2; Erlin-2; ERLIN2; ERLN2_HUMAN; HGNC:1356; MGC87072; NET32; SPFH 2; SPFH domain containing protein 2; SPFH domain family member 2; SPFH domain-containing protein 2; SPFH2; SPG18; Stomatin prohibitin flotillin HflC/K domain containing protein 2; Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2. |
| 纯化方法 | HPLC |
| 研究领域 | Neuroscience > Neurology process > Neurodegenerative disease > Alzheimer's disease Neuroscience > Neurology process > Neurodegenerative disease > Parkinson's disease Neuroscience > Neurology process > Neurodegenerative disease > Prions Signal Transduction > Adapters > Transmembrane Signal Transduction > Protein Trafficking > Vesicle Transport > Coat Proteins |
| 亚基 | Interacts with activated ITPR1, independently of the degree of ITPR1 polyubiquitination (By similarity). Forms a heteromeric complex with ERLIN1. In complex with ERLIN1, interacts with RNF170. |
| 亚细胞定位 | Endoplasmic reticulum membrane. Associated with lipid raft-like domains of the endoplasmic reticulum membrane. |
| 组织特异性 | Ubiquitous. |
| 相似性 | Belongs to the band 7/mec-2 family. |
| 功能 | Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Also involved in ITPR1 degradation by the ERAD pathway. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | SPFH2 is a ubiquitously expressed 339 amino acid protein that belongs to the band 7/mec-2 family. Localized to lipid raft-like domains in the membrane of the endoplasmic reticulum (ER), SPFH2 plays a crucial role in the ER-associated degradation (ERAD) pathway that removes metabolically regulated and aberrant proteins from the ER. Specifically, SPFH2 associates with IP3R-I (Inositol 1,4,5-triphosphate receptor I), a substrate of the ERAD pathway, and facilitates its polyubiquitination and subsequent degradation. Three isoforms of SPFH2 are expressed due to alternative splicing events. |
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SPFH2 Antibody Blocking Peptide(bs-10720P)-500ug
￥880
