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- Bioss
- bs-1319P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-1319P |
| 英文名称 | MAPK4 Antibody Blocking Peptide |
| 中文名称 | 丝裂原活化蛋白激酶4封闭多肽 |
| 英文别名 | Mitogen-activated protein kinase 4; Extracellular signal-regulated kinase 4; ERK-4; MAP kinase isoform p63; p63-MAPK; ERK-4; ERK3; Erk3 related; ERK4; Extracellular signal regulated kinase 4; MAP kinase 4; MAPK 4; MAPK4; Mitogen activated protein kinase 4; MK04_HUMAN; p63 MAPK; p63MAPK; PRKM4; A330097D03Rik; Erk3; p63Mapk; Prkm4. |
| 性状 | Lyophilized |
| 纯化方法 | HPLC |
| 亚基 | Homodimer. Heterodimer with ERK3/MAPK6. Interacts with (via FRIEDE motif) MAPKAPK5. |
| 亚细胞定位 | Cytoplasm. Nucleus. Note=Translocates to the cytoplasm following interaction with MAPKAPK5. |
| 组织特异性 | High expression in heart and brain. |
| 翻译后修饰 | Phosphorylated at Ser-186 by PAK1, PAK2 and PAK3 resulting in catalytic activation. Phosphorylated by MAPKAPK5 at other sites. |
| 相似性 | Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. Contains 1 protein kinase domain. |
| 功能 | Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK4/MAPK4 is phosphorylated at Ser-186 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK4/MAPK4. May promote entry in the cell cycle (By similarity). |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | Mitogen-activated protein kinase 4 is a member of the mitogen-activated protein kinase family. Tyrosine kinase growth factor receptors activate mitogen-activated protein kinases which then translocate into the nucleus where it phosphorylates nuclear targets. [provided by RefSeq, Jul 2008] |
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MAPK4 Antibody Blocking Peptide(bs-1319P)-500ug
￥880
