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- bs-11351P
- 2025年10月16日
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500ug
| 产品编号 | bs-11351P |
| 英文名称 | LRRC7 Antibody Blocking Peptide |
| 中文名称 | 层粘连相关多肽蛋白1封闭多肽 |
| 英文别名 | Densin 180; Densin; Densin-180; densin180; DKFZp686I1147; KIAA1365; Lamin associated polypeptide 1; LAP 1; Leucine rich repeat containing 7; Leucine rich repeat containing protein 7; Leucine-rich repeat-containing protein 7; Lrrc 7; Lrrc7; LRRC7_HUMAN; MGC144918; OTTHUMP00000065336; OTTHUMP00000065337; OTTHUMP00000065338; Protein Lap 1; Protein lap1. |
| 纯化方法 | HPLC |
| 亚基 | Interacts with CAMKII, CNKSR2 and DLG4 (By similarity). Interacts with CTNND2/Catenin delta-2. Forms a complex with N-cadherin through CTNND2. |
| 亚细胞定位 | Cytoplasm. Cell junction > synapse > postsynaptic cell membrane > postsynaptic density. |
| 组织特异性 | Brain-specific. Isoform 3 is ubiquitously expressed. |
| 相似性 | Belongs to the LAP (LRR and PDZ) protein family. Contains 17 LRR (leucine-rich) repeats. Contains 1 PDZ (DHR) domain. |
| 功能 | Required for normal synaptic spine architecture and function. Necessary for DISC1 and GRM5 localization to postsynaptic density complexes and for both N-methyl D-aspartate receptor-dependent and metabotropic glutamate receptor-dependent long term depression. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Densin-180 is a synaptic transmembrane protein that is tightly associated with the postsynaptic density in CNS neurons and is postulated to function as a synaptic adhesion molecule. Densin-180 is a brain-specific momber of the O-sialoglycoprotein family which is highly concentrated at synapses along dendrites. The sequence of densin-180 contains 17 leucine-rich repeats, a sialomucin domain, an apparent transmembrane domain, and a PDZ (PSD-95, DIg, Z0-1) domain. The PDZ domain contributes to its binding to a-actinin. The intracellular portion of densin-180, CaMKIIa, interacts with a-actinin at distinct binding sites and, together, they form a ternary complex stabilized by multiple interactions. |
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LRRC7 Antibody Blocking Peptide(bs-11351P)-500ug
￥880
