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- Bioss
- bs-11346P
- 2025年10月16日
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500ug
| 产品编号 | bs-11346P |
| 英文名称 | EGFLAM/Pikachurin Antibody Blocking Peptide |
| 中文名称 | 皮卡丘素封闭多肽 |
| 英文别名 | fibronectin type-III and laminin G-like domain-containing protein; Agrin-like protein; AGRINL; AGRNL; EGF-like; EGF-like, fibronectin type III and laminin G domains; EGF-like, fibronectin type-III and laminin G-like domain-containing protein; EGFLA_HUMAN; EGFLAM; FLJ39155; Pikachurin. |
| 纯化方法 | HPLC |
| 研究领域 | Neuroscience > Cell Type Marker > Neuron marker > Synapse marker Neuroscience > Sensory System > Visual system Signal Transduction > Cytoskeleton / ECM > Extracellular Matrix > ECM Proteins > Other ECM Proteins |
| 亚基 | Interacts with DAG1 alpha-dystroglycan |
| 亚细胞定位 | Secreted; extracellular space; extracellular matrix. Cell junction > synapse. Detected in the synaptic cleft of the ribbon synapse around the postsynaptic terminals of bipolar cells. Colocalizes with BSN, CTBP2 and DAG1 in photoreceptor synaptic terminals. |
| 翻译后修饰 | O-glycosylated; contains chondroitin sulfate and heparan sulfate. |
| 相似性 | Contains 3 EGF-like domains. Contains 2 fibronectin type-III domains. Contains 3 laminin G-like domains. |
| 功能 | Involved in both the retinal photoreceptor ribbon synapse formation and physiological functions of visual perception. Necessary for proper bipolar dendritic tip apposition to the photoreceptor ribbon synapse. Promotes matrix assembly and cell adhesiveness. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | EGFLAM is a 1,017 amino acid secreted protein containing three EGF-like domains, two fibronectin type-III domains, and three laminin G-like domains. Colocalizing with bassoon, CtBP and dystroglycan in photoreceptor synaptic terminals, EGFLAM is involved in retinal photoreceptor ribbon synapse formation. EGFLAM may also promote matrix assembly and cell adhesion. Existing as five alternatively spliced isoforms, the gene encoding EGFLAM maps to human chromosome 5p13.2. Chromosome 5 makes up approximately 6% of the human genome and contains 181 million base pairs, which encode 1,000 genes. Cockayne syndrome, Treacher Collins syndrome, acute myelogenous leukemias and myelodysplastic syndrome are associated with genes present on chromosome 5. |
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EGFLAM/Pikachurin Antibody Blocking Peptide(bs-11346P)-500ug
￥880
