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- Bioss
- bs-11333P
- 2025年10月16日
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- 规格：
500ug
| 产品编号 | bs-11333P |
| 英文名称 | SNAP91/AP180 Antibody Blocking Peptide |
| 中文名称 | 装配衔接蛋白180封闭多肽 |
| 英文别名 | AP 180; AP3; Assembly Protein 180 kDa; Assembly Protein AP180; CALM; Clathrin coat assembly protein; Clathrin coat assembly protein AP180; Clathrin coat associated protein AP180; DKFZp781O051; F120; KIAA0656; NP185; pp155; SNAP 91; SNAP91; 91kDa synaptosomal associated protein; Synaptosomal associated protein 91 kD homolog; Synaptosomal associated protein 91 kDa homolog; AP180_HUMAN. |
| 纯化方法 | HPLC |
| 亚基 | Binds AP2A2. Interacts with AP2B1; clathrin competes with SNAP91 (By similarity). |
| 亚细胞定位 | Component of the coat surrounding the cytoplasmic face of coated vesicles in the plasma membrane. |
| 翻译后修饰 | Thr-310 can be modified by the addition of N-acetylglucosamine which can be further phosphorylated. There is no evidence for direct Thr-310 phosphorylation (By similarity). |
| 相似性 | Contains 1 ENTH (epsin N-terminal homology) domain. |
| 功能 | AP180 is a clathrin binding phospho-protein and faciliates the formation of clathrin coats. This protein is also known as pp155, NP185, F1-20, and AP-3. During neurotransmitter release synaptic vesicles fuse with the presynaptic plasma membrane. A whole protein machinery consisting of amphiphysin, clathrin, endophilin and synaptojanin is involved in the subsequent endocytotic recycling of the synaptic vesicles. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Clathrin-coated pits and vesicles are assembled for receptor-mediated endocytosis through interaction with Clathrin associated protein complexes. Vesicle transport is mediated from the trans-Golgi network by the adapter complex AP-1 and from the plasma membrane by the AP-2 complex. The AP-1 and AP-2 adapter protein complexes consist of Clathrin binding Adaptin proteins (g and b1 for AP-1, a and b2 for AP-2) and two smaller subunits known as AP50 and AP17. The a and b Adaptin chains have a similar two-domain organization with C-terminal domains that vary in both sequence and length. a-Adaptin splice variants A and C display variable relative expression levels and differential distribution in different tissues. AP-3 (also designated AP180 or F1-20) is a synapse-specific Clathrin assembly protein. The protein CALM (Clathrin assembly protein lymphoid myeloid leukemia) is highly homologous to AP180 and may also be involved in Clathrin assembly. |
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SNAP91/AP180 Antibody Blocking Peptide(bs-11333P)-500ug
￥880
