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- bs-10690P
- 2025年10月16日
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- 技术资料
- 规格：
500ug
| 产品编号 | bs-10690P |
| 英文名称 | phospho-EFNB1 (phospho Y317) Antibody Blocking Peptide |
| 中文名称 | 磷酸化Ephrin B1封闭多肽 |
| 英文别名 | phospho-Ephrin B1 (phospho Y317); Ephrin B (phospho Y317); p-Ephrin B (phospho Y317); phospho-Ephrin B1 (Tyr317); phospho-Ephrin B2(Tyr316); CEK5 ligand; EFNB1; ELK L; EphrinB; Ephrin-B; ELK ligand; ELKL; EPH related receptor tyrosine kinase ligand 2; Ephrin B Precursor; Ephrin B1; Ephrin B2; LERK 2; LERK2; EFNB1_HUMAN; EFNB2_HUMAN. |
| 纯化方法 | HPLC |
| 亚基 | Interacts with GRIP1 and GRIP2. Binds to Nipah virus G protein. |
| 亚细胞定位 | Membrane; Single-pass type I membrane protein. |
| 组织特异性 | Highly expressed in brain; expressed in embryonic floor plate, roof plate and hindbrain segments. |
| 翻译后修饰 | Inducible phosphorylation of tyrosine residues in the cytoplasmic domain. |
| 相似性 | Belongs to the ephrin family. Contains 1 ephrin RBD (ephrin receptor-binding) domain. |
| 功能 | Binds to the receptor tyrosine kinases EPHB1 and EPHA1. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons.
Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neiGHBoring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to the receptor tyrosine kinases EPHB3 (preferred), EPHB1 and EPHA1. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Ephrin B proteins are thought to play key roles in cellular functions as diverse as neuronal migration and blood vessel development. Ephrin B molecules expressed at the membrane surface bind to the Ephrin B family receptors on target cells during cell to cell contact. This interaction leads to cell signaling in the target cell but also generates a reverse signal in the cell expressing Ephrin B on its surface. This reverse signaling event is thought to be critical for vessel maturation and neuronal development. Importantly, tyrosine phosphorylation of Ephrin B is thought to be a critical component of this reverse signaling event. Recent work demonstrated that Tyr331 of Ephrin B was phosphorylated in HEK293 cells after stimulation by the soluble Ephrin B2 receptor tyrosine kinase. |
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phospho-EFNB1 (phospho Y317) Antibody Blocking Peptide(bs-10690P)-500ug
￥1080
