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- Bioss
- bs-10685P
- 2025年10月16日
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- 规格：
500ug
| 产品编号 | bs-10685P |
| 英文名称 | SOCS6 Antibody Blocking Peptide |
| 中文名称 | 细胞因子信号传导抑制蛋白6封闭多肽 |
| 英文别名 | CIS-4; CIS4; Cish4; Cytokine inducible SH2 protein 4; Cytokine-inducible SH2 protein 4; HSPC060; SOCS-4; SOCS-6; SOCS4; Socs6; SOCS6_HUMAN; SSI4; STAI4; STAT induced STAT inhibitor 4; STAT4; STATI4; Suppressor of cytokine signaling 4; Suppressor of cytokine signaling 6. |
| 纯化方法 | HPLC |
| 研究领域 | Epigenetics and Nuclear Signaling > Nuclear Signaling Pathways > STATs Signal Transduction > Adapters > Cytoplasmic Signal Transduction > Signaling Pathway > Nuclear Signaling > STATs |
| 亚基 | Interacts with RBCK1. Interacts with phosphorylated IRS4. Interacts with PIM3. Interacts with KIT (phosphorylated). |
| 相似性 | Contains 1 SH2 domain.
Contains 1 SOCS box domain. |
| 功能 | SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates KIT degradation by ubiquitination of the tyrosine-phosphorylated receptor. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The protein encoded by this gene contains a SH2 domain and a CIS homolog domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by GM-CSF and EPO in hematopoietic cells. A high expression level of this gene was found in factor-independent chronic myelogenous leukemia (CML) and erythroleukemia (HEL) cell lines. [provided by RefSeq, Jul 2008]. |
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SOCS6 Antibody Blocking Peptide(bs-10685P)-500ug
￥880
