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- bs-16685P
- 2025年10月16日
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- 规格：
500ug
| 产品编号 | bs-16685P |
| 英文名称 | IPO11 Antibody Blocking Peptide |
| 中文名称 | Ran结合蛋白11封闭多肽 |
| 英文别名 | Imp11; Importin 11; Importin-11; IPO11; IPO11_HUMAN; Ran binding protein 11; Ran-binding protein 11; RanBP11; SLRN; Synleurin. |
| 纯化方法 | HPLC |
| 研究领域 | Signal Transduction > Protein Trafficking > Nuclear Import / Export |
| 亚细胞定位 | Cytoplasm. Nucleus. |
| 相似性 | Belongs to the importin beta family. Contains 15 HEAT repeats. Contains 1 importin N-terminal domain. |
| 功能 | Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of UBE2E3, and of RPL12. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Importins, including IPO11, are a members of the karyopherin/importin-beta family of transport receptors (see KPNB1; 602738) that mediate nucleocytoplasmic transport of protein and RNA cargoes (Plafker and Macara, 2000 [PubMed 11032817]).[supplied by OMIM, Sep 2008] |
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IPO11 Antibody Blocking Peptide(bs-16685P)-500ug
￥880
