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- bs-13837P
- 2025年10月16日
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- 规格：
500ug
| 产品编号 | bs-13837P |
| 英文名称 | CENPM Antibody Blocking Peptide |
| 中文名称 | 着丝粒蛋白M封闭多肽 |
| 英文别名 | bK250D10.2; C22orf18; CENP M; CENPM_HUMAN; Centromere protein M; ICEN 39; ICEN39; Interphase centromere complex protein 39; MGC861; OTTHUMP00000028741; PANE 1; PANE1; Proliferation associated nuclear element 1; Proliferation associated nuclear element protein 1. |
| 纯化方法 | HPLC |
| 研究领域 | Epigenetics and Nuclear Signaling > Cell cycle > Chromosome Structure > Centromere Epigenetics and Nuclear Signaling > Chromosome Structure > Centromeres |
| 亚细胞定位 | Cytoplasmic and Nuclear. Note: Nuclear in non confluent cells and cytoplasmic in confluent or dividing cells. Localizes in the kinetochore domain of centromeres. |
| 组织特异性 | Isoform 3 is highly expressed in spleen, and intermediately in heart, prostate and ovary. Isoform 3 is highly expressed in resting CD19 B-cells and B-lineage chronic lymphocytic leukemia (B-CLL) cells and weakly expressed in activated B-cells. Isoform 1 is selectively expressed in activated CD19 cells and weakly in resting CD19 B-cells. |
| 功能 | CENPM (Centromere protein M) is a component of the CENPA-NAC (nucleosome associated) complex, a complex that plays a central role in kinetochore protein assembly, mitotic cell cycle progression and chromosome segregation. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The centromere is a specialized chromatin domain, present throughout the cell cycle, that acts as a platform on which the transient assembly of the kinetochore occurs during mitosis. All active centromeres are characterized by the presence of long arrays of nucleosomes in which CENPA (MIM 117139) replaces histone H3 (see MIM 601128). CENPM is an additional factor required for centromere assembly (Foltz et al., 2006 [PubMed 16622419]).[supplied by OMIM, Mar 2008] |
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CENPM Antibody Blocking Peptide(bs-13837P)-500ug
￥880
