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- Bioss
- bs-11823P
- 2025年10月16日
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- 规格：
500ug
| 产品编号 | bs-11823P |
| 英文名称 | CSDC2 Antibody Blocking Peptide |
| 中文名称 | 冷休克结构域蛋白C2封闭多肽 |
| 英文别名 | Cold shock domain containing C2 RNA binding; Cold shock domain containing protein C2; Cold shock domain-containing protein C2; CSDC 2; Csdc2; CSDC2_HUMAN; dJ347H13.2; PIPPIN; RNA binding protein PIPPin; RNA-binding protein PIPPin. |
| 纯化方法 | HPLC |
| 亚细胞定位 | Nucleus. Cytoplasm. PIPPin-RNA complexes are located to the nucleus. |
| 相似性 | Contains 1 CSD (cold-shock) domain. |
| 功能 | RNA-binding factor which binds specifically to the very 3'-UTR ends of both histone H1 and H3.3 mRNAs, encompassing the polyadenylation signal. Might play a central role in the negative regulation of histone variant synthesis in the developing brain. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | PIPPIN is a Y-box protein (also called cold-shock (CSD) domain-containing protein) and belongs to a family of highly conserved RNA-binding transcriptional regulators. Predominantly expressed in brain cells and localizing to the nucleus and the cytoplasm, PIPPIN contains two RNA-binding motifs, namely PIP1 and PIP2, and one CSD domain. PIPPIN functions as a nucleic acid binding regulatory factor and is believed to participate in brain maturation. More specifically, PIPPIN binds to the 3’-UTR ends of the mRNAs encoding Histone H1 and Histone H3.3. This interaction requires all of the PIPPIN domains to work in concert as one functional protein. In addition, PIPPIN can be sumoylated in a thyroid hormone (T3)-dependent manner. This suggests that PIPPIN modification in response to extracellular stimuli may modulate the regulation of protein synthesis. |
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CSDC2 Antibody Blocking Peptide(bs-11823P)-500ug
￥880
