- ￥880
- Bioss
- bs-11291P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-11291P |
| 英文名称 | HDC2/PHC2 Antibody Blocking Peptide |
| 中文名称 | 早期发育调控蛋白2/HDC2封闭多肽 |
| 英文别名 | HDC2; Early development regulatory protein 2; hPH2; early development regulator 2 (homolog of polyhomeotic 2); early development regulator 2 like; EDR2; MGC163502; mph2; PH2; PHC2; PHC2_HUMAN; polyhomeotic 2; polyhomeotic like 2; Polyhomeotic-like protein 2. |
| 纯化方法 | HPLC |
| 亚基 | Component of a PRC1-like complex. Interacts with CBX4. Interacts with BMI1, PCGF2, PHC1 and RNF2. Interacts with CHTOP (By similarity). Interacts with the N-terminal region of the SP1 transcription factor and with MAPKAPK2. |
| 亚细胞定位 | Nucleus. |
| 翻译后修饰 | Phosphorylated upon DNA damage, probably by ATM or ATR. |
| 相似性 | Contains 1 FCS-type zinc finger.
Contains 1 SAM (sterile alpha motif) domain. |
| 功能 | Component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | In Drosophila melanogaster, the 'Polycomb' group (PcG) of genes are part of a cellular memory system that is responsible for the stable inheritance of gene activity. PcG proteins form a large multimeric, chromatin-associated protein complex. The protein encoded by this gene has homology to the Drosophila PcG protein polyhomeotic' (Ph) and is known to heterodimerize with EDR1 and colocalize with BMI1 in interphase nuclei of human cells. The specific function in human cells has not yet been determined. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. |
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HDC2/PHC2 Antibody Blocking Peptide(bs-11291P)-500ug
￥880
