- ￥880
- Bioss
- bs-15185P
- 2025年10月16日
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500ug
| 产品编号 | bs-15185P |
| 英文名称 | C4BPA Antibody Blocking Peptide |
| 中文名称 | 补体C4BPA蛋白封闭多肽 |
| 英文别名 | C4b-binding protein alpha chain; C4bp; C4bpa; C4BPA_HUMAN; Complement component 4 binding protein; Proline-rich protein; PrP; RP11-164O23.4. |
| 纯化方法 | HPLC |
| 研究领域 | Immunology > Innate Immunity > Complement > Classical Pathway |
| 亚基 | Disulfide-linked complex of alpha and beta chains of 3 possible sorts: a 570 kDa complex of 7 alpha chains and 1 beta chain, a 530 kDa homoheptamer of alpha chains or a 500 kDa complex of 6 alpha chains and 1 beta chain. The central body of the alpha chain homopolymer supports tentacles, each with the binding site for C4b at the end. |
| 亚细胞定位 | Secreted. |
| 组织特异性 | Chylomicrons in the plasma. |
| 相似性 | Contains 8 Sushi (CCP/SCR) domains. |
| 功能 | Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | C4BPA is a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 amino acids. Along with a single, unique beta-chain, seven identical alpha-chains encoded by this gene assemble into the predominant isoform of C4b-binding protein, a multimeric protein that controls activation of the complement cascade through the classical pathway. The genes encoding both alpha and beta chains are located adjacent to each other on human chromosome 1 in the regulator of complement activation gene cluster. Two pseudogenes of this gene are also found in the cluster. |
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C4BPA Antibody Blocking Peptide(bs-15185P)-500ug
￥880
