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- bs-5713R-Bio
- 2025年10月15日
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100ul
| 产品编号 | bs-5713R-Bio |
| 英文名称 | HOXA5 Rabbit pAb, Biotin conjugated |
| 中文名称 | Biotin标记的同源异型盒基因HOXA5蛋白抗体 |
| 英文别名 | Homeo box 1C antibody Homeobox A5 antibody Homeobox protein HOXA5 antibody HOX 1 antibody HOX 1.3 antibody HOX 1C antibody HOX1 antibody HOX1.3 antibody HOX1C antibody; HXA5_HUMAN. |
| 产品应用 | WB=1:1000-5000, IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500, ELISA=1:500-5000 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human HOXA5 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cancer > Cell cycle > Cell cycle inhibitors > p53 pathway Epigenetics and Nuclear Signaling > Transcription > Domain Families > Developmental Families > HOX |
| 亚细胞定位 | Nucleus. |
| 相似性 | Belongs to the Antp homeobox family. Contains 1 homeobox DNA-binding domain. |
| 功能 | Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Also binds to its own promoter. Binds specifically to the motif 5'-CYYNATTA[TG]Y-3'. |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | HOXA5 upregulates both p53 promoter-reporter constructs and endogenous p53 synthesis, leading to apoptosis. HOXA5 is detectable in approximately one-third of primary tumors. Lack of HOXA5 expression strongly correlates with methylation of its promoter region, suggesting a causal role for methylation in the silencing of HOXA5 gene expression. HOXA5 expression is an important step in tumorigenesis and loss of expression of p53 in human breast cancer may be primarily due to lack of expression of HOXA5. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:1000-5000} |
| {IHC-P} | {1:100-500} |
| {IHC-F} | {1:100-500} |
| {IF} | {1:100-500} |
| {ELISA} | {1:500-5000} |
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文献和实验相关实验
- or triple-labeling immunofluorescence, it is necessary to use primary antibodies raised in different host species such as mouse, rabbit, and goat. However, in many cases, suitable primary antibodies raised in different species are unavailable
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HOXA5 Rabbit pAb, Biotin conjugated(bs-5713R-Bio)-100ul
￥2980
